Please use this identifier to cite or link to this item: doi:10.22028/D291-38686
Title: Glucose Homeostasis and Pancreatic Islet Size Are Regulated by the Transcription Factors Elk-1 and Egr-1 and the Protein Phosphatase Calcineurin
Author(s): Thiel, Gerald
Rössler, Oliver G.
Language: English
Title: International Journal of Molecular Sciences
Volume: 24
Issue: 1
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: Elk-1
pancreatic β-cells
islet size
glucose homeostasis
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Pancreatic β-cells synthesize and secrete insulin. A key feature of diabetes mellitus is the loss of these cells. A decrease in the number of β-cells results in decreased biosynthesis of insulin. Increasing the number of β-cells should restore adequate insulin biosynthesis leading to adequate insulin secretion. Therefore, identifying proteins that regulate the number of β-cells is a high priority in diabetes research. In this review article, we summerize the results of three sophisticated transgenic mouse models showing that the transcription factors Elk-1 and Egr-1 and the Ca2+/calmodulin-regulated protein phosphatase calcineurin control the formation of sufficiently large pancreatic islets. Impairment of the biological activity of Egr-1 and Elk-1 in pancreatic β-cells leads to glucose intolerance and dysregulation of glucose homeostasis, the process that maintains glucose concentration in the blood within a narrow range. Transgenic mice expressing an activated calcineurin mutant also had smaller islets and showed hyperglycemia. Calcineurin induces dephosphorylation of Elk-1 which subsequently impairs Egr-1 biosynthesis and the biological functions of Elk-1 and Egr-1 to regulate islet size and glucose homeostasis.
DOI of the first publication: 10.3390/ijms24010815
Link to this record: urn:nbn:de:bsz:291--ds-386860
ISSN: 1422-0067
Date of registration: 16-Jan-2023
Faculty: M - Medizinische Fakultät
Department: M - Medizinische Biochemie und Molekularbiologie
Professorship: M - Prof. Dr. Gerald Thiel
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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