Please use this identifier to cite or link to this item: doi:10.22028/D291-38628
Title: MTARC1 and HSD17B13 Variants Have Protective Effects on Non-Alcoholic Fatty Liver Disease in Patients Undergoing Bariatric Surgery
Author(s): Kalinowski, Piotr
Smyk, Wiktor
Nowosad, Małgorzata
Paluszkiewicz, Rafał
Michałowski, Łukasz
Ziarkiewicz-Wróblewska, Bogna
Weber, Susanne N.
Milkiewicz, Piotr
Lammert, Frank
Zieniewicz, Krzysztof
Krawczyk, Marcin
Language: English
Title: International Journal of Molecular Sciences
Volume: 23
Issue: 24
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: liver fibrosis
mitochondrial amidoxime-reducing component 1
weight-loss surgery
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: The severity of hepatic steatosis is modulated by genetic variants, such as patatin-like phospholipase domain containing 3 (PNPLA3) rs738409, transmembrane 6 superfamily member 2 (TM6SF2) rs58542926, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738. Recently, mitochondrial amidoxime reducing component 1 (MTARC1) rs2642438 and hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) rs72613567 polymorphisms were shown to have protective effects on liver diseases. Here, we evaluate these variants in patients undergoing bariatric surgery. A total of 165 patients who underwent laparoscopic sleeve gastrectomy and intraoperative liver biopsies and 314 controls were prospectively recruited. Genotyping was performed using TaqMan assays. Overall, 70.3% of operated patients presented with hepatic steatosis. NASH (non-alcoholic steatohepatitis) was detected in 28.5% of patients; none had cirrhosis. The increment of liver fibrosis stage was associated with decreasing frequency of the MTARC1 minor allele (p = 0.03). In multivariate analysis MTARC1 was an independent protective factor against fibrosis ≥ 1b (OR = 0.52, p = 0.03) and ≥1c (OR = 0.51, p = 0.04). The PNPLA3 risk allele was associated with increased hepatic steatosis, fibrosis, and NASH (OR = 2.22, p = 0.04). The HSD17B13 polymorphism was protective against liver injury as reflected by lower AST (p = 0.04) and ALT (p = 0.03) activities. The TM6SF2 polymorphism was associated with increased ALT (p = 0.04). In conclusion, hepatic steatosis is common among patients scheduled for bariatric surgery, but the MTARC1 and HSD17B13 polymorphisms lower liver injury in these individuals.
DOI of the first publication: 10.3390/ijms232415825
Link to this record: urn:nbn:de:bsz:291--ds-386286
ISSN: 1422-0067
Date of registration: 23-Dec-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Frank Lammert
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
ijms-23-15825.pdf797,73 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons