Please use this identifier to cite or link to this item: doi:10.22028/D291-38627
Title: The Influence of Acitretin on Brain Lipidomics in Adolescent Mice : Implications for Pediatric and Adolescent Dermatological Therapy
Author(s): Lauer, Anna A.
Nguyen, Vu Thu Thuy
Janitschke, Daniel
dos Santos Guilherme, Malena
Bachmann, Cornel M.
Grimm, Heike S.
Hartmann, Tobias
Endres, Kristina
Grimm, Marcus O. W.
Language: English
Title: International Journal of Molecular Sciences
Volume: 23
Issue: 24
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: acitretin
brain development
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with lower prevalence in children than in adults is hyperlipidemia. This might be based on the lack of comorbidities in young patients, but must not be neglected. Especially for the development of the human brain up to young adulthood, dysbalance of lipids might be deleterious. Here, we provide for the first time an in-depth analysis of the influence of subchronic acitretin-administration on lipid composition of brain parenchyma of young wild type mice. For comparison and to evaluate the systemic effect of the treatment, liver lipids were analogously investigated. As expected, triglycerides increased in liver as well as in brain and a non-significant increase in cholesterol was observed. However, specifically brain showed an increase in lyso-phosphatidylcholine and carnitine as well as in sphingomyelin. Group analysis of lipid classes revealed no statistical effects, while single species were tissue-dependently changed: effects in brain were in general more subtly as compared to those in liver regarding the mere number of changed lipid species. Thus, while the overall impact of acitretin seems comparably small regarding brain, the change in individual species and their role in brain development and maturation has to be considered.
DOI of the first publication: 10.3390/ijms232415535
Link to this record: urn:nbn:de:bsz:291--ds-386273
ISSN: 1422-0067
Date of registration: 23-Dec-2022
Description of the related object: Supplementary Materials
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Neurologie und Psychiatrie
Professorship: M - Prof. Dr. Tobias Hartmann
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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