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doi:10.22028/D291-38422
Titel: | Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides |
VerfasserIn: | Perniss, Alexander Liu, Shuya Boonen, Brett Keshavarz, Maryam Ruppert, Anna-Lena Timm, Thomas Pfeil, Uwe Soultanova, Aichurek Kusumakshi, Soumya Delventhal, Lucas Aydin, Öznur Pyrski, Martina Deckmann, Klaus Hain, Torsten Schmidt, Nadine Ewers, Christa Günther, Andreas Lochnit, Günter Chubanov, Vladimir Gudermann, Thomas Oberwinkler, Johannes Klein, Jochen Mikoshiba, Katsuhiko Leinders-Zufall, Trese Offermanns, Stefan Schütz, Burkhard Boehm, Ulrich Zufall, Frank Bufe, Bernd Kummer, Wolfgang |
Sprache: | Englisch |
Titel: | Immunity |
Bandnummer: | 52 |
Heft: | 4 |
Seiten: | 683-699 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2020 |
Freie Schlagwörter: | acetylcholine bitter receptors brush cells chemosensory cells formylated bacterial peptides formyl peptide receptors mucociliary clearance taste transduction trachea transient receptor potential cation channel subfamily M member 5 tuft cells |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Mucociliary clearance through coordinated ciliary beating is a major innate defense removing pathogens from the lower airways, but the pathogen sensing and downstream signaling mechanisms remain unclear. We identified virulence-associated formylated bacterial peptides that potently stimulated ciliary-driven transport in the mouse trachea. This innate response was independent of formyl peptide and taste receptors but depended on key taste transduction genes. Tracheal cholinergic chemosensory cells expressed these genes, and genetic ablation of these cells abrogated peptide-driven stimulation of mucociliary clearance. Trpm5-deficient mice were more susceptible to infection with a natural pathogen, and formylated bacterial peptides were detected in patients with chronic obstructive pulmonary disease. Optogenetics and peptide stimulation revealed that ciliary beating was driven by paracrine cholinergic signaling from chemosensory to ciliated cells operating through muscarinic M3 receptors independently of nerves. We provide a cellular and molecular framework that defines how tracheal chemosensory cells integrate chemosensation with innate defense. |
DOI der Erstveröffentlichung: | 10.1016/j.immuni.2020.03.005 |
URL der Erstveröffentlichung: | http://dx.doi.org/10.1016/j.immuni.2020.03.005 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-384228 hdl:20.500.11880/34671 http://dx.doi.org/10.22028/D291-38422 |
ISSN: | 1074-7613 |
Datum des Eintrags: | 7-Dez-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplemental Information |
In Beziehung stehendes Objekt: | https://ars.els-cdn.com/content/image/1-s2.0-S1074761320301187-mmc1.pdf https://ars.els-cdn.com/content/image/1-s2.0-S1074761320301187-mmc2.xlsx https://ars.els-cdn.com/content/image/1-s2.0-S1074761320301187-mmc4.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Experimentelle und Klinische Pharmakologie und Toxikologie M - Physiologie |
Professur: | M - Prof. Dr. Ulrich Boehm M - Prof. Dr. Trese Leinders-Zufall M - Prof. Dr. Frank Zufall |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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