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Titel: Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides
VerfasserIn: Perniss, Alexander
Liu, Shuya
Boonen, Brett
Keshavarz, Maryam
Ruppert, Anna-Lena
Timm, Thomas
Pfeil, Uwe
Soultanova, Aichurek
Kusumakshi, Soumya
Delventhal, Lucas
Aydin, Öznur
Pyrski, Martina
Deckmann, Klaus
Hain, Torsten
Schmidt, Nadine
Ewers, Christa
Günther, Andreas
Lochnit, Günter
Chubanov, Vladimir
Gudermann, Thomas
Oberwinkler, Johannes
Klein, Jochen
Mikoshiba, Katsuhiko
Leinders-Zufall, Trese
Offermanns, Stefan
Schütz, Burkhard
Boehm, Ulrich
Zufall, Frank
Bufe, Bernd
Kummer, Wolfgang
Sprache: Englisch
Titel: Immunity
Bandnummer: 52
Heft: 4
Seiten: 683-699
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2020
Freie Schlagwörter: acetylcholine
bitter receptors
brush cells
chemosensory cells
formylated bacterial peptides
formyl peptide receptors
mucociliary clearance
taste transduction
trachea
transient receptor potential cation channel subfamily M member 5
tuft cells
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Mucociliary clearance through coordinated ciliary beating is a major innate defense removing pathogens from the lower airways, but the pathogen sensing and downstream signaling mechanisms remain unclear. We identified virulence-associated formylated bacterial peptides that potently stimulated ciliary-driven transport in the mouse trachea. This innate response was independent of formyl peptide and taste receptors but depended on key taste transduction genes. Tracheal cholinergic chemosensory cells expressed these genes, and genetic ablation of these cells abrogated peptide-driven stimulation of mucociliary clearance. Trpm5-deficient mice were more susceptible to infection with a natural pathogen, and formylated bacterial peptides were detected in patients with chronic obstructive pulmonary disease. Optogenetics and peptide stimulation revealed that ciliary beating was driven by paracrine cholinergic signaling from chemosensory to ciliated cells operating through muscarinic M3 receptors independently of nerves. We provide a cellular and molecular framework that defines how tracheal chemosensory cells integrate chemosensation with innate defense.
DOI der Erstveröffentlichung: 10.1016/j.immuni.2020.03.005
URL der Erstveröffentlichung: http://dx.doi.org/10.1016/j.immuni.2020.03.005
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-384228
hdl:20.500.11880/34671
http://dx.doi.org/10.22028/D291-38422
ISSN: 1074-7613
Datum des Eintrags: 7-Dez-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplemental Information
In Beziehung stehendes Objekt: https://ars.els-cdn.com/content/image/1-s2.0-S1074761320301187-mmc1.pdf
https://ars.els-cdn.com/content/image/1-s2.0-S1074761320301187-mmc2.xlsx
https://ars.els-cdn.com/content/image/1-s2.0-S1074761320301187-mmc4.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Experimentelle und Klinische Pharmakologie und Toxikologie
M - Physiologie
Professur: M - Prof. Dr. Ulrich Boehm
M - Prof. Dr. Trese Leinders-Zufall
M - Prof. Dr. Frank Zufall
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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