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Titel: Theoretical modelling of competitive microbial range expansion with heterogeneous mechanical interactions
VerfasserIn: Maikranz, E.
Santen, L.
Sprache: Englisch
Titel: Physical Biology
Bandnummer: 18 (2021)
Heft: 1
Verlag/Plattform: IOP Publishing
Erscheinungsjahr: 2020
Freie Schlagwörter: range expansion
competition
biofilm growth
Eden model
passive mobility
cell sorting
pushing
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Microbial range expansion experiments provide insight into the complex link between dynamic structure, pattern formation and evolutionary dynamics of growing populations. In this work, we develop a theoretical model in order to investigate the interplay of growth statistics and mechanical interactions which are implemented as division driven pushing and swapping of cells. For the case of the competitive growth of a strongly and a weakly interacting strain we investigate the influence of different mean division times, as well as different mechanical interactions on the development of the colony. Our results show that the susceptibility to cell division induced pushing has a much stronger influence on the structure of the colony than cell sorting towards the colony’s perimeter. Motivated by microbial range expansion experiments of Neisseria gonorrhoeae bacteria, we also consider the influence of mutating cells on the structure of the colony. We show that the outgrowth of the three different strains is strongly influenced by the relative strengths of their mechanical interaction. The experimentally observed patterns are reproduced for mechanical interactions of the mutants, which range between those of the strongly and weakly interacting strain.
DOI der Erstveröffentlichung: 10.1088/1478-3975/abcae9
URL der Erstveröffentlichung: http://dx.doi.org/10.1088/1478-3975/abcae9
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-383347
hdl:20.500.11880/34592
http://dx.doi.org/10.22028/D291-38334
ISSN: 1478-3975
1478-3967
Datum des Eintrags: 1-Dez-2022
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Physik
Professur: NT - Prof. Dr. Ludger Santen
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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