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doi:10.22028/D291-38317
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Titel: | Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model |
VerfasserIn: | Linz, Benedikt Hohl, Mathias Lang, Lisa Wong, Dickson W. L. Nickel, Alexander G. De La Torre, Carolina Sticht, Carsten Wirth, Klaus Boor, Peter Maack, Christoph Speer, Thimoteus ![]() Schotten, Ulrich Sanders, Prashanthan Böhm, Michael Linz, Dominik |
Sprache: | Englisch |
In: | |
Titel: | Heart Rhythm |
Bandnummer: | 18 (2021) |
Heft: | 3 |
Seiten: | 455-464 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2020 |
Freie Schlagwörter: | Atrial fibrillation Night-to-night variability Obstructive sleep apnea Rats Substrate |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background High night-to-night variability in obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF). Obstructive apneas are characterized by intermittent deoxygenation-reoxygenation and intrathoracic pressure swings during ineffective inspiration against occluded upper airways. Objective We elucidated the effect of repeated exposure to transient OSA conditions simulated by intermittent negative upper airway pressure (INAP) on the development of an AF substrate. Methods INAP (48 events/4 h; apnea-hypopnea index 12 events/h) was applied in sedated spontaneously breathing rats (2% isoflurane) to simulate mild-to-moderate OSA. Rats without INAP served as a control group (CTR). In an acute test series (ATS), rats were either killed immediately (n = 9 per group) or after 24 hours of recovery (ATS-REC: n = 5 per group). To simulate high night-to-night variability in OSA, INAP applications (n = 10; 24 events/4 h; apnea-hypopnea index 6/h) were repeated every second day for 3 weeks in a chronic test series (CTS). Results INAP increased atrial oxidative stress acutely, represented in decreases of reduced to oxidized glutathione ratio (ATS: INAP: 0.33 ± 0.05 vs CTR: 1 ± 0.26; P = .016), which was reversible after 24 hours (ATS-REC: INAP vs CTR; P = .274). Although atrial oxidative stress did not accumulate in the CTS, atrial histological analysis revealed increased cardiomyocyte diameters, reduced connexin 43 expression, and increased interstitial fibrosis formation (CTS: INAP 7.0% ± 0.5% vs CTR 5.1% ± 0.3%; P = .013), which were associated with longer inducible AF episodes (CTS: INAP: 11.65 ± 4.43 seconds vs CTR: 0.7 ± 0.33 seconds; P = .033). Conclusion Acute simulation of OSA was associated with reversible atrial oxidative stress. Cumulative exposure to these transient OSA-related conditions resulted in AF substrates and was associated with increased AF susceptibility. Mild-to-moderate OSA with high night-to-night variability may deserve intensive management to prevent atrial substrate development. |
DOI der Erstveröffentlichung: | 10.1016/j.hrthm.2020.10.011 |
URL der Erstveröffentlichung: | http://dx.doi.org/10.1016/j.hrthm.2020.10.011 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-383179 hdl:20.500.11880/34575 http://dx.doi.org/10.22028/D291-38317 |
ISSN: | 1547-5271 |
Datum des Eintrags: | 30-Nov-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary data |
In Beziehung stehendes Objekt: | https://ars.els-cdn.com/content/image/1-s2.0-S1547527120309747-mmc1.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Michael Böhm M - Dr. med. Dr. sc.nat. Timo Speer |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons