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Titel: Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model
VerfasserIn: Linz, Benedikt
Hohl, Mathias
Lang, Lisa
Wong, Dickson W. L.
Nickel, Alexander G.
De La Torre, Carolina
Sticht, Carsten
Wirth, Klaus
Boor, Peter
Maack, Christoph
Speer, Thimoteus UdsID
Schotten, Ulrich
Sanders, Prashanthan
Böhm, Michael
Linz, Dominik
Sprache: Englisch
In:
Titel: Heart Rhythm
Bandnummer: 18 (2021)
Heft: 3
Seiten: 455-464
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2020
Freie Schlagwörter: Atrial fibrillation
Night-to-night variability
Obstructive sleep apnea
Rats
Substrate
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background High night-to-night variability in obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF). Obstructive apneas are characterized by intermittent deoxygenation-reoxygenation and intrathoracic pressure swings during ineffective inspiration against occluded upper airways. Objective We elucidated the effect of repeated exposure to transient OSA conditions simulated by intermittent negative upper airway pressure (INAP) on the development of an AF substrate. Methods INAP (48 events/4 h; apnea-hypopnea index 12 events/h) was applied in sedated spontaneously breathing rats (2% isoflurane) to simulate mild-to-moderate OSA. Rats without INAP served as a control group (CTR). In an acute test series (ATS), rats were either killed immediately (n = 9 per group) or after 24 hours of recovery (ATS-REC: n = 5 per group). To simulate high night-to-night variability in OSA, INAP applications (n = 10; 24 events/4 h; apnea-hypopnea index 6/h) were repeated every second day for 3 weeks in a chronic test series (CTS). Results INAP increased atrial oxidative stress acutely, represented in decreases of reduced to oxidized glutathione ratio (ATS: INAP: 0.33 ± 0.05 vs CTR: 1 ± 0.26; P = .016), which was reversible after 24 hours (ATS-REC: INAP vs CTR; P = .274). Although atrial oxidative stress did not accumulate in the CTS, atrial histological analysis revealed increased cardiomyocyte diameters, reduced connexin 43 expression, and increased interstitial fibrosis formation (CTS: INAP 7.0% ± 0.5% vs CTR 5.1% ± 0.3%; P = .013), which were associated with longer inducible AF episodes (CTS: INAP: 11.65 ± 4.43 seconds vs CTR: 0.7 ± 0.33 seconds; P = .033). Conclusion Acute simulation of OSA was associated with reversible atrial oxidative stress. Cumulative exposure to these transient OSA-related conditions resulted in AF substrates and was associated with increased AF susceptibility. Mild-to-moderate OSA with high night-to-night variability may deserve intensive management to prevent atrial substrate development.
DOI der Erstveröffentlichung: 10.1016/j.hrthm.2020.10.011
URL der Erstveröffentlichung: http://dx.doi.org/10.1016/j.hrthm.2020.10.011
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-383179
hdl:20.500.11880/34575
http://dx.doi.org/10.22028/D291-38317
ISSN: 1547-5271
Datum des Eintrags: 30-Nov-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary data
In Beziehung stehendes Objekt: https://ars.els-cdn.com/content/image/1-s2.0-S1547527120309747-mmc1.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Michael Böhm
M - Dr. med. Dr. sc.nat. Timo Speer
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



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