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doi:10.22028/D291-38310
Titel: | Associations between multiple sclerosis and incidence of heart diseases : Systematic review and meta-analysis of observational studies |
VerfasserIn: | Rapp, Daniel Michels, Sebastian Schöpe, Jakob Schwingshackl, Lukas Tumani, Hayrettin Senel, Makbule |
Sprache: | Englisch |
Titel: | Multiple Sclerosis and Related Disorders |
Bandnummer: | 56 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | Multiple sclerosis Cardiovascular diseases Meta-analysis Comorbidities Heart diseases |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Observational studies have described associations between multiple sclerosis (MS) and heart diseases, but the results were mixed. Methods: Medline, Embase, and Cochrane CENTRAL were searched up to 5 October 2020 according to a protocol (PROSPERO registration number CRD42020184493). We included longitudinal non-randomized studies of exposure comparing the incidence of acquired heart diseases between people with multiple sclerosis (pwMS) and people without multiple sclerosis. We used ROBINS-E and the GRADE approach to assess risk of bias and the certainty of evidence, respectively. Data were pooled using random-effect models. Results: Of 5,159 studies, nine studies met the inclusion criteria. MS was associated with an increased risk for myocardial infarction (HR 1.6, 95% CI 1.2 to 2.0, I2 86%, n = 1,209,079) and heart failure (HR 1.7, 95% CI 1.3 to 2.2, I2 49%, n = 489,814). The associations were more pronounced among women and younger people in subgroup analyses. We found no difference for ischemic heart disease (HR 1.0, 95% CI 0.8 to 1.4, I2 86%, n = 679,378) and bradycardia (HR 1.5, 95% CI 0.4 to 5.0, I2 50%, n = 187,810). The risk of atrial fibrillation was lower in pwMS (HR 0.7, 95% CI 0.6 to 0.8, I2 0%, n = 354,070), but the risk of bias was high, and the certainty of evidence was rated as very low. One study found more cases of infectious endocarditis among pwMS (HR 1.2, 95% CI 1.0 to 1.4, n = 83,712). Conclusions: Myocardial infarction and heart failure should be considered in people with multiple sclerosis during follow-up examinations. |
DOI der Erstveröffentlichung: | 10.1016/j.msard.2021.103279 |
URL der Erstveröffentlichung: | http://dx.doi.org/10.1016/j.msard.2021.103279 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-383103 hdl:20.500.11880/34567 http://dx.doi.org/10.22028/D291-38310 |
ISSN: | 2211-0348 |
Datum des Eintrags: | 30-Nov-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary materials |
In Beziehung stehendes Objekt: | https://ars.els-cdn.com/content/image/1-s2.0-S2211034821005460-mmc1.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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1-s2.0-S2211034821005460-main.pdf | 3,25 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons