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Titel: Associations between multiple sclerosis and incidence of heart diseases : Systematic review and meta-analysis of observational studies
VerfasserIn: Rapp, Daniel
Michels, Sebastian
Schöpe, Jakob
Schwingshackl, Lukas
Tumani, Hayrettin
Senel, Makbule
Sprache: Englisch
Titel: Multiple Sclerosis and Related Disorders
Bandnummer: 56
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2021
Freie Schlagwörter: Multiple sclerosis
Cardiovascular diseases
Meta-analysis
Comorbidities
Heart diseases
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: Observational studies have described associations between multiple sclerosis (MS) and heart diseases, but the results were mixed. Methods: Medline, Embase, and Cochrane CENTRAL were searched up to 5 October 2020 according to a protocol (PROSPERO registration number CRD42020184493). We included longitudinal non-randomized studies of exposure comparing the incidence of acquired heart diseases between people with multiple sclerosis (pwMS) and people without multiple sclerosis. We used ROBINS-E and the GRADE approach to assess risk of bias and the certainty of evidence, respectively. Data were pooled using random-effect models. Results: Of 5,159 studies, nine studies met the inclusion criteria. MS was associated with an increased risk for myocardial infarction (HR 1.6, 95% CI 1.2 to 2.0, I2 86%, n = 1,209,079) and heart failure (HR 1.7, 95% CI 1.3 to 2.2, I2 49%, n = 489,814). The associations were more pronounced among women and younger people in subgroup analyses. We found no difference for ischemic heart disease (HR 1.0, 95% CI 0.8 to 1.4, I2 86%, n = 679,378) and bradycardia (HR 1.5, 95% CI 0.4 to 5.0, I2 50%, n = 187,810). The risk of atrial fibrillation was lower in pwMS (HR 0.7, 95% CI 0.6 to 0.8, I2 0%, n = 354,070), but the risk of bias was high, and the certainty of evidence was rated as very low. One study found more cases of infectious endocarditis among pwMS (HR 1.2, 95% CI 1.0 to 1.4, n = 83,712). Conclusions: Myocardial infarction and heart failure should be considered in people with multiple sclerosis during follow-up examinations.
DOI der Erstveröffentlichung: 10.1016/j.msard.2021.103279
URL der Erstveröffentlichung: http://dx.doi.org/10.1016/j.msard.2021.103279
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-383103
hdl:20.500.11880/34567
http://dx.doi.org/10.22028/D291-38310
ISSN: 2211-0348
Datum des Eintrags: 30-Nov-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary materials
In Beziehung stehendes Objekt: https://ars.els-cdn.com/content/image/1-s2.0-S2211034821005460-mmc1.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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