Please use this identifier to cite or link to this item: doi:10.22028/D291-38309
Title: Engineered spider silk-based 2D and 3D materials prevent microbial infestation
Author(s): Kumari, Sushma
Lang, Gregor
DeSimone, Elise
Spengler, Christian
Trossmann, Vanessa T.
Lücker, Susanne
Hudel, Martina
Jacobs, Karin
Krämer, Norbert
Scheibel, Thomas
Language: English
Title: Materials Today
Volume: 41
Pages: 21-33
Publisher/Platform: Elsevier
Year of Publication: 2020
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Biofilm formation, especially of antimicrobiotic-resistant microbial strains, are a major problem in health care. Therefore, there is great interest in developing advanced materials that are selectively inhibiting microbial adhesion to surfaces, but at the same time promoting mammalian cell growth. In nature, some spider silks have evolved to repel microbes, a feature that could be used in biomaterials. To unravel how microbe repellence can be achieved in engineered spider silk, different recombinant spider silk proteins based on the consensus sequences of Araneus diadematus dragline silk proteins (fibroin 3 and 4) were processed into 2D-patterned films and 3D-hydrogels. Strikingly, protein structure characteristics on the nanoscale are the basis for the detected microbe-repellence. Designed spider silk materials promoted mammalian cell attachment and proliferation while inhibiting microbial infestation, demonstrating the great potential of these engineered spider silk-based materials as bio-selective microbial-resistant coatings in biomedical as well as technical applications.
DOI of the first publication: 10.1016/j.mattod.2020.06.009
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-383092
ISSN: 1369-7021
Date of registration: 30-Nov-2022
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Karin Jacobs
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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