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Titel: Computational genomics-proteomics and Phylogeny analysis of twenty one mycobacterial genomes (Tuberculosis & non Tuberculosis strains)
VerfasserIn: Zakham, Fathiah
Aouane, Othmane
Ussery, David
Benjouad, Abdelaziz
Ennaji, Moulay Mustapha
Sprache: Englisch
Titel: Microbial informatics and experimentation
Bandnummer: 2
Seiten: 1-9
Verlag/Plattform: BMC
Erscheinungsjahr: 2012
Freie Schlagwörter: BLAST matrix
Comparative genome analysis
Evolution
Mycobacterium tuberculosis
Pan- core genome
Phylogeny
DDC-Sachgruppe: 500 Naturwissenschaften
600 Technik
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The genus Mycobacterium comprises different species, among them the most contagious and infectious bacteria. The members of the complex Mycobacterium tuberculosis are the most virulent microorganisms that have killed human and other mammals since millennia. Additionally, with the many different mycobacterial sequences available, there is a crucial need for the visualization and the simplification of their data. In this present study, we aim to highlight a comparative genome, proteome and phylogeny analysis between twenty-one mycobacterial (Tuberculosis and non tuberculosis) strains using a set of computational and bioinformatics tools (Pan and Core genome plotting, BLAST matrix and phylogeny analysis).
Results Considerably the result of pan and core genome Plotting demonstrated that less than 1250 Mycobacterium gene families are conserved across all species, and a total set of about 20,000 gene families within the Mycobacterium pan-genome of twenty one mycobacterial genomes.Viewing the BLAST matrix a high similarity was found among the species of the complex Mycobacterium tuberculosis and less conservation is found with other slow growing pathogenic mycobacteria. Phylogeny analysis based on both protein conservation, as well as rRNA clearly resolve known relationships between slow growing mycobacteria.
Conclusion Mycobacteria include important pathogenic species for human and animals and the Mycobacterium tuberculosis complex is the most cause of death of the humankind. The comparative genome analysis could provide a new insight for better controlling and preventing these diseases.
DOI der Erstveröffentlichung: 10.1186/2042-5783-2-7
URL der Erstveröffentlichung: https://microbialinformaticsj.biomedcentral.com/articles/10.1186/2042-5783-2-7
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-382077
hdl:20.500.11880/34488
http://dx.doi.org/10.22028/D291-38207
ISSN: 2042-5783
Datum des Eintrags: 24-Nov-2022
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Physik
Professur: NT - Prof. Dr. Christian Wagner
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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