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Titel: Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis
VerfasserIn: Thurner, Lorenz
Zaks, Marina
Preuß, Klaus-Dieter
Fadle, Natalie
Regitz, Evi
Ong, Mei Fang
Pfreundschuh, Michael
Assmann, Gunter
Sprache: Englisch
Titel: Arthritis research & therapy
Bandnummer: 15
Seiten: 1-9
Verlag/Plattform: BMC
Erscheinungsjahr: 2013
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Psoriatic arthritis (PsA) is a distinctive inflammatory arthritis which may typically develop in a subgroup of individuals suffering from psoriasis. We recently described progranulin autoantibodies (PGRN-Abs) in the sera of patients with different autoimmune diseases including seronegative polyarthritis. In the present study we investigated the occurrence of PGRN-Abs in PsA.
PGRN-Abs were determined in 260 patients with PsA, 100 patients with psoriasis without arthritic manifestations (PsC) and 97 healthy controls using a recently described ELISA. PGRN plasma levels were determined from subgroups by a commercially available ELISA-kit. Possible functional effects of PGRN-antibodies were analysed in vitro by tumour necrosis factor (TNF)-α mediated cytotoxicity assays using WEHI-S and HT1080 cells.
PGRN-Abs were detected with relevant titres in 50/260 (19.23%) patients with PsA, but in 0/100 patients with psoriasis without arthritic manifestations (P = 0.0001). All PGRN-Abs belonged to immunoglobulin G (IgG). PGRN-Abs were significantly more frequent in PsA patients with enthesitis or dactylitis. PGRN-Abs were also more frequent in PsA patients receiving treatment with TNF-α-blockers than in patients treated without TNF-α-blockers (20.8% versus 17.4%; P = 0.016). PGRN plasma levels were significantly lower in PGRN-Ab-positive patients with PsA than in healthy controls and patients with psoriasis without arthritic manifestations (P < 0.001), indicating a neutralizing effect of PGRN-Abs. Moreover cytotoxicity assays comparing PGRN-antibody positive with negative sera from matched patients with PsA, clearly showed a proinflammatory effect of PGRN antibodies.
Neutralizing PGRN-Abs occur with relevant titres in a subgroup of patients with PsA, but not in patients without arthritic manifestations (PsC). PGRN-Ab-positive patients had more frequent enthesitis or dactylitis. TNF-α-induced cytotoxicity assays demonstrated that the protective effects of progranulin were inhibited by serum containing PGRN-Abs. This suggests that PGRN-Ab might not only be useful as a diagnostic and prognostic marker, but may provide a proinflammatory environment in a subgroup of patients with PsA.
DOI der Erstveröffentlichung: 10.1186/ar4406
URL der Erstveröffentlichung: https://arthritis-research.biomedcentral.com/articles/10.1186/ar4406
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-382057
hdl:20.500.11880/34486
http://dx.doi.org/10.22028/D291-38205
ISSN: 1478-6354
Datum des Eintrags: 24-Nov-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Stephan Stilgenbauer
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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