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Titel: Management of Germ Cell Tumours of the Testes in Adult Patients : German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy
VerfasserIn: Kliesch, Sabine
Schmidt, Stefanie
Wilborn, Doris
Aigner, Clemens
Albrecht, Walter
Bedke, Jens
Beintker, Matthias
Beyersdorff, Dirk
Bokemeyer, Carsten
Busch, Jonas
Classen, Johannes
de Wit, Maike
Dieckmann, Klaus-Peter
Diemer, Thorsten
Dieing, Anette
Gockel, Matthias
Göckel-Beining, Bernt
Hakenberg, Oliver W.
Heidenreich, Axel
Heinzelbecker, Julia
Herkommer, Kathleen
Hermanns, Thomas
Kaufmann, Sascha
Kornmann, Marko
Kotzerke, Jörg
Krege, Susanne
Kristiansen, Glen
Lorch, Anja
Müller, Arndt-Christian
Oechsle, Karin
Ohloff, Timur
Oing, Christoph
Otto, Ulrich
Pfister, David
Pichler, Renate
Recken, Heinrich
Rick, Oliver
Rudolph, Yvonne
Ruf, Christian
Schirren, Joachim
Schmelz, Hans
Schmidberger, Heinz
Schrader, Mark
Schweyer, Stefan
Seeling, Stefanie
Souchon, Rainer
Winter, Christian
Wittekind, Christian
Zengerling, Friedemann
Zermann, D. H.
Zillmann, Roger
Albers, Peter
Sprache: Englisch
Titel: Urologia Internationalis
Bandnummer: 105
Heft: 3-4
Seiten: 181–191
Verlag/Plattform: Karger
Erscheinungsjahr: 2021
Freie Schlagwörter: Germ cell tumour of the testes
Seminoma
Non-seminoma
Metastasis
Extragonadal tumours
Stromal tumours
Therapy
Follow-up
Toxicity
Quality of life
Palliative care
Supportive therapy
Systematic review
Guideline
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Objectives: We developed the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up of germ cell tumours (GCT) of the testes in adult patients. We present the guideline content in 2 separate publications. The present second part summarizes therecommendations for the treatment of advanced disease stages and for the management of follow-up and late effects. Materials and Methods: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search in March 2018), were provided. Thirty-one experts, who were entitled to vote, rated the final clinical recommendations and statements. Results: Here we present the treatment recommendations separately for patients with metastatic seminoma and non-seminomatous GCT (stages IIA/B and IIC/III), for restaging and treatment of residual masses, and for relapsed and refractory disease stages. The recommendations also cover extragonadal and sex cord/stromal tumours, the management of follow-up and toxicity, quality-of-life aspects, palliative care, and supportive therapy. Conclusion: Physicians and other medical service providers who are involved in the diagnostics, treatment, and follow-up of GCT (all stages, outpatient and inpatient care as well as rehabilitation) are the users of the present guideline. The guideline also comprises quality indicators for measuring the implementation of the guideline recommendations in routine clinical care; these data will be presented in a future publication.
DOI der Erstveröffentlichung: 10.1159/000511245
URL der Erstveröffentlichung: https://www.karger.com/Article/FullText/511245
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-379129
hdl:20.500.11880/34278
http://dx.doi.org/10.22028/D291-37912
ISSN: 1423-0399
0042-1138
Datum des Eintrags: 9-Nov-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://karger.figshare.com/ndownloader/files/26150837
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Urologie und Kinderurologie
Professur: M - Prof. Dr. Michael Stöckle
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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