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doi:10.22028/D291-37795
Titel: | The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease : an analysis by the Global Germ Cell Tumor Collaborative Group (G3) |
VerfasserIn: | Seidel, Christoph Daugaard, Gedske Nestler, Tim Tryakin, Alexey Fedyanin, Mikhail Fankhauser, Christian Daniel Hermanns, Thomas Aparicio, Jorge Heinzelbecker, Julia Paffenholz, Pia Heidenreich, Axel De Giorgi, Ugo Cathomas, Richard Lorch, Anja Fingerhut, Anna Gayer, Fabian Bremmer, Felix Giannatempo, Patrizia Necchi, Andrea Raggi, Daniele Aurilio, Gaetano Casadei, Chiara Hentrich, Marcus Tran, Ben Dieckmann, Klaus-Peter Brito, Margarido Ruf, Christian Mazzocca, Alessandro Vincenzi, Bruno Stahl, Olof Bokemeyer, Carsten Oing, Christoph |
Sprache: | Englisch |
Titel: | World Journal of Urology |
Bandnummer: | 39 |
Heft: | 9 |
Seiten: | 3407–3414 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | Seminoma Lactate dehydrogenase Prognostic markers Upper limit of normal |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Purpose The prognostic signifcance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defned. We investigated the prognostic impact of LDH levels prior to frst-line systemic treatment and other clinical characteristics in this subset of patients. Methods Files from two registry studies and one single-institution database were analyzed retrospectively. Uni- and multivariate analyses were conducted to identify patient characteristics associated with recurrence free survival (RFS), overall survival (OS), and complete response rate (CRR). Results The dataset included 351 metastatic seminoma patients with a median follow-up of 5.36 years. Five-year RFS, OS and CRR were 82%, 89% and 52%, respectively. Explorative analysis revealed a cut-of LDH level of<2.5 upper limit of normal (ULN) (n=228) vs.≥2.5 ULN (n=123) to be associated with a signifcant diference concerning OS associated with 5-years OS rates of 93% vs. 83% (p=0.001) which was confrmed in multivariate analysis (HR 2.87; p=0.004). Furthermore, the cut-of LDH<2.5 ULN vs.≥2.5 ULN correlated with RFS and CRR associated with a 5-years RFS rate and CRR of 76% vs. 86% (p=0.012) and 32% vs. 59% (p ≤ 0.001), respectively. Conclusions LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratifcation. |
DOI der Erstveröffentlichung: | 10.1007/s00345-021-03635-3 |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s00345-021-03635-3 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-377951 hdl:20.500.11880/34181 http://dx.doi.org/10.22028/D291-37795 |
ISSN: | 1433-8726 0724-4983 |
Datum des Eintrags: | 3-Nov-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Urologie und Kinderurologie |
Professur: | M - Prof. Dr. Michael Stöckle |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s00345-021-03635-3.pdf | 817,17 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons