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Titel: The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease : an analysis by the Global Germ Cell Tumor Collaborative Group (G3)
VerfasserIn: Seidel, Christoph
Daugaard, Gedske
Nestler, Tim
Tryakin, Alexey
Fedyanin, Mikhail
Fankhauser, Christian Daniel
Hermanns, Thomas
Aparicio, Jorge
Heinzelbecker, Julia
Paffenholz, Pia
Heidenreich, Axel
De Giorgi, Ugo
Cathomas, Richard
Lorch, Anja
Fingerhut, Anna
Gayer, Fabian
Bremmer, Felix
Giannatempo, Patrizia
Necchi, Andrea
Raggi, Daniele
Aurilio, Gaetano
Casadei, Chiara
Hentrich, Marcus
Tran, Ben
Dieckmann, Klaus-Peter
Brito, Margarido
Ruf, Christian
Mazzocca, Alessandro
Vincenzi, Bruno
Stahl, Olof
Bokemeyer, Carsten
Oing, Christoph
Sprache: Englisch
Titel: World Journal of Urology
Bandnummer: 39
Heft: 9
Seiten: 3407–3414
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2021
Freie Schlagwörter: Seminoma
Lactate dehydrogenase
Prognostic markers
Upper limit of normal
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Purpose The prognostic signifcance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defned. We investigated the prognostic impact of LDH levels prior to frst-line systemic treatment and other clinical characteristics in this subset of patients. Methods Files from two registry studies and one single-institution database were analyzed retrospectively. Uni- and multivariate analyses were conducted to identify patient characteristics associated with recurrence free survival (RFS), overall survival (OS), and complete response rate (CRR). Results The dataset included 351 metastatic seminoma patients with a median follow-up of 5.36 years. Five-year RFS, OS and CRR were 82%, 89% and 52%, respectively. Explorative analysis revealed a cut-of LDH level of<2.5 upper limit of normal (ULN) (n=228) vs.≥2.5 ULN (n=123) to be associated with a signifcant diference concerning OS associated with 5-years OS rates of 93% vs. 83% (p=0.001) which was confrmed in multivariate analysis (HR 2.87; p=0.004). Furthermore, the cut-of LDH<2.5 ULN vs.≥2.5 ULN correlated with RFS and CRR associated with a 5-years RFS rate and CRR of 76% vs. 86% (p=0.012) and 32% vs. 59% (p ≤ 0.001), respectively. Conclusions LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratifcation.
DOI der Erstveröffentlichung: 10.1007/s00345-021-03635-3
URL der Erstveröffentlichung: https://link.springer.com/article/10.1007/s00345-021-03635-3
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-377951
hdl:20.500.11880/34181
http://dx.doi.org/10.22028/D291-37795
ISSN: 1433-8726
0724-4983
Datum des Eintrags: 3-Nov-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Urologie und Kinderurologie
Professur: M - Prof. Dr. Michael Stöckle
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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