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Titel: Ribes nigrum L. Extract-Mediated Green Synthesis and Antibacterial Action Mechanisms of Silver Nanoparticles
VerfasserIn: Hovhannisyan, Zaruhi
Timotina, Marina
Manoyan, Jemma
Gabrielyan, Lilit
Petrosyan, Margarit
Kusznierewicz, Barbara
Bartoszek, Agnieszka
Jacob, Claus
Ginovyan, Mikayel
Trchounian, Karen
Sahakyan, Naira
Nasim, Muhammad Jawad
Sprache: Englisch
Titel: Antibiotics
Bandnummer: 11
Heft: 10
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: silver nanoparticles
Ribes nigrum
natural products
phytochemical investigation
antimicrobial
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Silver nanoparticles (Ag NPs) represent one of the most widely employed metal-based engineered nanomaterials with a broad range of applications in different areas of science. Plant extracts (PEs) serve as green reducing and coating agents and can be exploited for the generation of Ag NPs. In this study, the phytochemical composition of ethanolic extract of black currant (Ribes nigrum) leaves was determined. The main components of extract include quercetin rutinoside, quercetin hexoside, quercetin glucuronide, quercetin malonylglucoside and quercitrin. The extract was subsequently employed for the green synthesis of Ag NPs. Consequently, R. nigrum leaf extract and Ag NPs were evaluated for potential antibacterial activities against Gram-negative bacteria (Escherichia coli ATCC 25922 and kanamycin-resistant E. coli pARG-25 strains). Intriguingly, the plant extract did not show any antibacterial effect, whilst Ag NPs demonstrated significant activity against tested bacteria. Biogenic Ag NPs affect the ATPase activity and energy-dependent H+ - fluxes in both strains of E. coli, even in the presence of N,N0 -dicyclohexylcarbodiimide (DCCD). Thus, the antibacterial activity of the investigated Ag NPs can be explained by their impact on the membrane-associated properties of bacteria.
DOI der Erstveröffentlichung: 10.3390/antibiotics11101415
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-377146
hdl:20.500.11880/34142
http://dx.doi.org/10.22028/D291-37714
ISSN: 2079-6382
Datum des Eintrags: 27-Okt-2022
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Claus Jacob
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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