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Titel: Human chorionic gonadotropin-positive seminoma patients : A registry compiled by the global germ cell tumor collaborative group (G3)
VerfasserIn: Seidel, Christoph
Daugaard, Gedske
Nestler, Tim
Tryakin, Alexey
Fedyanin, Mikhail
Fankhauser, Christian
Hermanns, Thomas
Aparicio, Jorge
Heinzelbecker, Julia
Paffenholz, Pia
Heidenreich, Axel
De Giorgi, Ugo
Cathomas, Richard
Lorch, Anja
Fingerhut, Anna
Gayer, Fabian
Bremmer, Felix
Giannatempo, Patrizia
Necchi, Andrea
Aurilio, Gaetano
Casadei, Chiara
Tran, Ben
Dieckmann, Klaus-Peter
Brito, Margarida
Ruf, Christian
Oing, Christoph
Bokemeyer, Carsten
Sprache: Englisch
Titel: European Journal of Cancer
Bandnummer: 132
Seiten: 127-135
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2020
Freie Schlagwörter: Seminoma
Lactate dehydrogenase
Prognostic factor
Human chorionic gonadotropin
Beta-hCG
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background The prognostic role of human chorionic gonadotropin (hCG) and lactate dehydrogenase (LDH) serum levels in seminoma patients remains uncertain. This observational study evaluates the prognostic impact of tumour marker levels, and other clinicopathological findings, in hCG-positive seminoma patients. Methods Seminoma patients with serum hCG levels above normal at first diagnosis were eligible for recruitment. Statistical analysis, including multivariate regression, was performed to identify risk factors. Primary end-points were overall survival (OS) and recurrence-free survival (RFS). Results We recruited 1031 hCG-positive patients (stage I: n = 586; stage II + III: n = 427) diagnosed between 1981 and 2018. In metastatic disease, LDH levels ≥3 above upper normal limit (UNL) pre- (n = 109) or post-orchiectomy (n = 73) and patients aged ≥40 years (n = 187) were associated with poor prognosis: 5-year OS rates of 84% (LDH ≥3 UNL pre-orchiectomy) versus 92% (<3 UNL pre-orchiectomy) (hazard ratio [HR]: 3.155, [95% confidence interval {CI}: 1.28–7.75], P = 0.012), 82% (≥3 UNL post-orchiectomy) versus 92% (<3 UNL post-orchiectomy) (HR: 6.877, [95% CI: 1.61–29.34]; P = 0.009) and 86% (≥40 years) versus 91% (<40 years) (HR: 6.870, [95% CI: 1.45–13.37], P = 0.009), respectively. A subset of patients with hCG levels ≥2000 IU/l pre-orchiectomy (n = 17) exhibited a poor prognosis, with 5-year OS rates of 73% (≥2000 IU/l) versus 94% (<2000 IU/l) (HR: 3.936, [95% CI: 1.02–12.61], P = 0.047). Conclusions Age and LDH levels are significantly associated with poor prognosis in hCG-positive seminoma patients. A small number of patients, with levels of hCG ≥2000 IU/l, may represent a separate prognostic subgroup associated with impaired survival rates.
DOI der Erstveröffentlichung: 10.1016/j.ejca.2020.03.022
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/abs/pii/S0959804920301635
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-377379
hdl:20.500.11880/34127
http://dx.doi.org/10.22028/D291-37737
ISSN: 0959-8049
Datum des Eintrags: 26-Okt-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Urologie und Kinderurologie
Professur: M - Prof. Dr. Michael Stöckle
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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