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doi:10.22028/D291-37734
Titel: | PD1/PD-L1 Axis in Uro-oncology |
VerfasserIn: | Junker, Kerstin Eckstein, Markus Fiorentino, Michelangelo Montironi, Rodolfo |
Sprache: | Englisch |
Titel: | Current Drug Targets |
Bandnummer: | 21 |
Heft: | 13 |
Seiten: | 1294-1300 |
Verlag/Plattform: | Bentham Science |
Erscheinungsjahr: | 2020 |
Freie Schlagwörter: | Checkpoint inhibition PD-L1 bladder cancer prostate cancer kidney cancer testicular germ cell tumors penile cancer |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | The immune system is important to control tumor development and progression in humans. However, tumor cells and cells of the tumor microenvironment can induce immune escape mechanisms including activation of immune checkpoints such as PD-1/PD-L1. Based on this knowledge, new immune therapies, including PD-1 and PD-L1 inhibition, have been developed and are already recommended as a standard treatment in metastatic bladder and kidney cancer patients. In addition to its role as a therapeutic target, PD-L1 seems to be a prognostic parameter although data are controversial. Only little is known about signaling pathways inducing PD-L1 expression in tumor cells on one hand and about its functional role for tumor cells itself. However, the understanding of the complex biological function of PD-L1 will improve therapeutic options in urological malignancies. This review is giving an overview of the current knowledge concerning the PD-1/PD-L1 axis in urological tumors including bladder, kidney, prostate, testicular and penile cancer. |
DOI der Erstveröffentlichung: | 10.2174/1389450121666200326123700 |
URL der Erstveröffentlichung: | https://www.eurekaselect.com/article/105491 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-377345 hdl:20.500.11880/34124 http://dx.doi.org/10.22028/D291-37734 |
ISSN: | 1389-4501 |
Datum des Eintrags: | 26-Okt-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Urologie und Kinderurologie |
Professur: | M - Prof. Dr. Michael Stöckle |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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