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doi:10.22028/D291-37660
Titel: | Spatial Cytoskeleton Organization Supports Targeted Intracellular Transport |
VerfasserIn: | Hafner, Anne E. Rieger, Heiko |
Sprache: | Englisch |
Titel: | Biophysical Journal |
Bandnummer: | 114 |
Heft: | 6 |
Seiten: | 1420-1432 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2018 |
DDC-Sachgruppe: | 500 Naturwissenschaften |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | The efficiency of intracellular cargo transport from specific sources to target locations is strongly dependent upon molecular motor-assisted motion along the cytoskeleton. Radial transport along microtubules and lateral transport along the filaments of the actin cortex underneath the cell membrane are characteristic for cells with a centrosome. The interplay between the specific cytoskeleton organization and the motor performance results in a spatially inhomogeneous intermittent search strategy. To analyze the efficiency of such intracellular search strategies, we formulate a random velocity model with intermittent arrest states. We evaluate efficiency in terms of mean first passage times for three different, frequently encountered intracellular transport tasks: 1) the narrow escape problem, which emerges during cargo transport to a synapse or other specific region of the cell membrane; 2) the reaction problem, which considers the binding time of two particles within the cell; and 3) the reaction-escape problem, which arises when cargo must be released at a synapse only after pairing with another particle. Our results indicate that cells are able to realize efficient search strategies for various intracellular transport tasks economically through a spatial cytoskeleton organization that involves only a narrow actin cortex rather than a cell body filled with randomly oriented actin filaments. |
DOI der Erstveröffentlichung: | 10.1016/j.bpj.2018.01.042 |
URL der Erstveröffentlichung: | https://www.sciencedirect.com/science/article/pii/S0006349518302066 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-376608 hdl:20.500.11880/34075 http://dx.doi.org/10.22028/D291-37660 |
ISSN: | 0006-3495 |
Datum des Eintrags: | 19-Okt-2022 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Physik |
Professur: | NT - Prof. Dr. Heiko Rieger |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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