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Titel: Spatial Cytoskeleton Organization Supports Targeted Intracellular Transport
VerfasserIn: Hafner, Anne E.
Rieger, Heiko
Sprache: Englisch
Titel: Biophysical Journal
Bandnummer: 114
Heft: 6
Seiten: 1420-1432
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2018
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The efficiency of intracellular cargo transport from specific sources to target locations is strongly dependent upon molecular motor-assisted motion along the cytoskeleton. Radial transport along microtubules and lateral transport along the filaments of the actin cortex underneath the cell membrane are characteristic for cells with a centrosome. The interplay between the specific cytoskeleton organization and the motor performance results in a spatially inhomogeneous intermittent search strategy. To analyze the efficiency of such intracellular search strategies, we formulate a random velocity model with intermittent arrest states. We evaluate efficiency in terms of mean first passage times for three different, frequently encountered intracellular transport tasks: 1) the narrow escape problem, which emerges during cargo transport to a synapse or other specific region of the cell membrane; 2) the reaction problem, which considers the binding time of two particles within the cell; and 3) the reaction-escape problem, which arises when cargo must be released at a synapse only after pairing with another particle. Our results indicate that cells are able to realize efficient search strategies for various intracellular transport tasks economically through a spatial cytoskeleton organization that involves only a narrow actin cortex rather than a cell body filled with randomly oriented actin filaments.
DOI der Erstveröffentlichung: 10.1016/j.bpj.2018.01.042
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/pii/S0006349518302066
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-376608
hdl:20.500.11880/34075
http://dx.doi.org/10.22028/D291-37660
ISSN: 0006-3495
Datum des Eintrags: 19-Okt-2022
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Physik
Professur: NT - Prof. Dr. Heiko Rieger
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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