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Titel: “Just Antimicrobial is not Enough” Revisited : From Antimicrobial Polymers to Microstructured Dual‐Functional Surfaces, Self‐Regenerating Polymer Surfaces, and Polymer Materials with Switchable Bioactivity
VerfasserIn: Zober, Maria
Lienkamp, Karen UdsID
Sprache: Englisch
In:
Titel: Macromolecular Chemistry and Physics
Bandnummer: 223
Heft: 19
Verlag/Plattform: Wiley
Erscheinungsjahr: 2022
Freie Schlagwörter: antimicrobial polymers
nonfouling polymers
polymer coatings
polymer multilayers
polymer surfaces
polymeric materials
polyzwitterions
self-regeneration
surface modification
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Biofilm formation can be slowed down by restricting protein adhesion on a surface, or by antimicrobial/biocidal activity of the material (among other methods). In this progress report, the recent work on alternatives to single component antimicrobial or protein-repellent polymer materials is presented. These are microstructured bifunctional polymer surfaces and self-regenerating polymer multilayer stacks. The microstructured polymer surfaces consist of antimicrobial, protein-adhesive polymer patches, and nonfouling, protein repellent-polymer patches. By carefully balancing the size and architecture of the adhesive and repellent patches, materials with simultaneous antimicrobial activity and strong protein repellency are obtained. At similar polymer patch sizes, protein adhesion is lower on hydrogels with a low elastic modulus than on polymer monolayers attached to stiff substrates. Surface-regenerating polymer multilayer stacks are constructed from alternating layers of antimicrobial polymer hydrogels and degradable, soluble, or depolymerizable sacrificial layers. Top layer shedding, which imitates reptiles shedding their skin, rejuvenates the surface, and regenerates the antimicrobial function of the material. Layer shedding form such materials in solution is a competition between two thermodynamic minima, top layer reattachment and top layer removal. The outcome of each shedding event depends on the kinetics of the sacrificial layer disintegration.
DOI der Erstveröffentlichung: 10.1002/macp.202200051
URL der Erstveröffentlichung: https://onlinelibrary.wiley.com/doi/10.1002/macp.202200051
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-376514
hdl:20.500.11880/34066
http://dx.doi.org/10.22028/D291-37651
ISSN: 1521-3935
1022-1352
Datum des Eintrags: 18-Okt-2022
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Materialwissenschaft und Werkstofftechnik
Professur: NT - Dr. Karen Lienkamp
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons