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doi:10.22028/D291-37651
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Datei | Beschreibung | Größe | Format | |
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Macro Chemistry Physics - 2022 - Zober - Just Antimicrobial is not Enough Revisited From Antimicrobial Polymers to.pdf | 1,52 MB | Adobe PDF | Öffnen/Anzeigen |
Titel: | “Just Antimicrobial is not Enough” Revisited : From Antimicrobial Polymers to Microstructured Dual‐Functional Surfaces, Self‐Regenerating Polymer Surfaces, and Polymer Materials with Switchable Bioactivity |
VerfasserIn: | Zober, Maria Lienkamp, Karen ![]() |
Sprache: | Englisch |
In: | |
Titel: | Macromolecular Chemistry and Physics |
Bandnummer: | 223 |
Heft: | 19 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | antimicrobial polymers nonfouling polymers polymer coatings polymer multilayers polymer surfaces polymeric materials polyzwitterions self-regeneration surface modification |
DDC-Sachgruppe: | 500 Naturwissenschaften |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Biofilm formation can be slowed down by restricting protein adhesion on a surface, or by antimicrobial/biocidal activity of the material (among other methods). In this progress report, the recent work on alternatives to single component antimicrobial or protein-repellent polymer materials is presented. These are microstructured bifunctional polymer surfaces and self-regenerating polymer multilayer stacks. The microstructured polymer surfaces consist of antimicrobial, protein-adhesive polymer patches, and nonfouling, protein repellent-polymer patches. By carefully balancing the size and architecture of the adhesive and repellent patches, materials with simultaneous antimicrobial activity and strong protein repellency are obtained. At similar polymer patch sizes, protein adhesion is lower on hydrogels with a low elastic modulus than on polymer monolayers attached to stiff substrates. Surface-regenerating polymer multilayer stacks are constructed from alternating layers of antimicrobial polymer hydrogels and degradable, soluble, or depolymerizable sacrificial layers. Top layer shedding, which imitates reptiles shedding their skin, rejuvenates the surface, and regenerates the antimicrobial function of the material. Layer shedding form such materials in solution is a competition between two thermodynamic minima, top layer reattachment and top layer removal. The outcome of each shedding event depends on the kinetics of the sacrificial layer disintegration. |
DOI der Erstveröffentlichung: | 10.1002/macp.202200051 |
URL der Erstveröffentlichung: | https://onlinelibrary.wiley.com/doi/10.1002/macp.202200051 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-376514 hdl:20.500.11880/34066 http://dx.doi.org/10.22028/D291-37651 |
ISSN: | 1521-3935 1022-1352 |
Datum des Eintrags: | 18-Okt-2022 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Materialwissenschaft und Werkstofftechnik |
Professur: | NT - Dr. Karen Lienkamp |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons