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Titel: The prominent role of the S100A8/S100A9-CD147 axis in the progression of penile cancer
VerfasserIn: Mohr, Tobias
Zwick, Anabel
Hans, Muriel Charlotte
Bley, Isabelle Ariane
Braun, Felix Leon
Khalmurzaev, Oybek
Matveev, Vsevolod Borisovich
Loertzer, Philine
Pryalukhin, Alexey
Hartmann, Arndt
Geppert, Carol-Immanuel
Loertzer, Hagen
Wunderlich, Heiko
Naumann, Carsten Maik
Kalthoff, Holger
Junker, Kerstin UdsID
Smola, Sigrun
Lohse, Stefan
Sprache: Englisch
In:
Titel: Frontiers in Oncology
Bandnummer: 12
Verlag/Plattform: Frontiers
Erscheinungsjahr: 2022
Freie Schlagwörter: penile cancer
myeloid-derived suppressor cells
neutrophils
calprotectin
HPVrelated cancer
S100A8
S100A9
CD147
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Currently, no established biomarkers are recommended for the routine diagnosis of penile carcinoma (PeCa). The rising incidence of this human papillomavirus (HPV)–related cancer entity highlights the need for promising candidates. The Calprotectin subunits S100A8 and S100A9 mark myeloid-derived suppressor cells in other HPV-related entities while their receptor CD147 was discussed to identify patients with PeCa at a higher risk for poor prognoses and treatment failure. We thus examined their expression using immunohistochemistry staining of PeCa specimens from 74 patients on tissue microarrays of the tumor center, the invasion front, and lymph node metastases. Notably, whereas the tumor center was significantly more intensively stained than the invasion front, lymph node metastases were thoroughly positive for both S100 subunits. An HPV-positive status combined with an S100A8+S100A9+ profile was related with an elevated risk for metastases. We observed several PeCa specimens with S100A8+S100A9+-infiltrating immune cells overlapping with CD15 marking neutrophils. The S100A8+S100A9+CD15+ profile was associated with dedifferentiated and metastasizing PeCa, predominantly of HPV-associated subtype. These data suggest a contribution of neutrophil-derived suppressor cells to the progression of HPV-driven penile carcinogenesis. CD147 was elevated, expressed in PeCa specimens, prominently at the tumor center and in HPV-positive PeCa cell lines. CD147+HPV+ PeCa specimens were with the higher-frequency metastasizing cancers. Moreover, an elevated expression of CD147 of HPV-positive PeCa cell lines correlated negatively with the susceptibility to IgA-based neutrophil-mediated tumor cell killing. Finally, stratifying patients regarding their HPV/S100A8/S100A9/CD15/CD147 profile may help identify patients with progressing cancer and tailor immunotherapeutic treatment strategies.
DOI der Erstveröffentlichung: 10.3389/fonc.2022.891511
URL der Erstveröffentlichung: https://www.frontiersin.org/articles/10.3389/fonc.2022.891511/full
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-376212
hdl:20.500.11880/34039
http://dx.doi.org/10.22028/D291-37621
ISSN: 2234-943X
Datum des Eintrags: 17-Okt-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://www.frontiersin.org/articles/file/downloadfile/891511_supplementary-materials_datasheets_1_docx/octet-stream/Data%20Sheet%201.docx/2/891511
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Infektionsmedizin
M - Pathologie
M - Urologie und Kinderurologie
Professur: M - Prof. Dr. Sigrun Smola
M - Prof. Dr. Michael Stöckle
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons