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Titel: Cranial MRI in Childhood Acute Leukemia during Treatment and Follow-Up Including the Impact of Intrathecal MTX : A Single-Center Study and Review of the Literature
VerfasserIn: Mergen, Marvin
Scheid, Sascha
Schubmehl, Hannah
Backens, Martin
Reith, Wolfgang
Graf, Norbert
Sprache: Englisch
Titel: Cancers
Bandnummer: 14
Heft: 19
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: cerebral MRI
childhood acute leukemias
ventricular width
morphologic alterations
intrathecal MTX
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Due to high survival rates, long-term sequelae, especially neurotoxicity, need to be considered in childhood acute leukemias. In this retrospective analysis of morphologic changes of the brain in children treated for acute leukemias, we included 94 patients (77 ALL, 17 AML; 51 male, 43 female; median age: 5 years) from a single center. We analyzed 170 cranial MRI scans (T2, FLAIR axial) for morphologic alterations of the brain and variations of the ventricular width (GDAH). In addition, the corresponding literature was reviewed. More than 50% of all patients showed cerebral pathomorphologies (CP). They were seen more often in children with ALL (55.8%), ≤ 6 years of age (60.8%), in relapse (58.8%) or after CNS irradiation (75.0%) and included white matter changes, brain atrophy, sinus vein thrombosis and ischemic events. GDAH significantly enlarged mainly in children up to 6 years, with relapse, high-risk leukemias or ALL patients. However, GDAH can normalize again. The number of intrathecal Methotrexate applications (≤12 vs. >12) showed no correlation to morphologic alterations besides a significant increase in GDAH (−0.3 vs. 0.9 mm) between the first and last follow-up MRI in ALL patients receiving >12 ith. MTX applications. The role of ith. MTX on CP needs to be further investigated and correlated to the neurocognitive outcome of children with acute leukemias.
DOI der Erstveröffentlichung: 10.3390/cancers14194688
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-375813
hdl:20.500.11880/34034
http://dx.doi.org/10.22028/D291-37581
ISSN: 2072-6694
Datum des Eintrags: 17-Okt-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/cancers14194688/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
M - Radiologie
Professur: M - Prof. Dr. Norbert Graf
M - Prof. Dr. Wolfgang Reith
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons