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doi:10.22028/D291-37611
Titel: | Dynamic vessel adaptation in synthetic arteriovenous networks |
VerfasserIn: | Fredrich, Thierry Welter, Michael Rieger, Heiko |
Sprache: | Englisch |
Titel: | Journal of Theoretical Biology |
Bandnummer: | 483 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2019 |
Freie Schlagwörter: | Vascular response Capillary bed radii regulation Blood vessel radii change in networks Optimal capillary volume density |
DDC-Sachgruppe: | 500 Naturwissenschaften |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Blood vessel networks of living organisms continuously adapt their structure under the influence of hemodynamic and metabolic stimuli. For a fixed vessel arrangement, blood flow characteristics still depend crucially on the morphology of each vessel. Vessel diameters adapt dynamically according to internal and external stimuli: Endothelial wall shear stress, intravascular pressure, flow-dependent metabolic stimuli, and electrical stimuli conducted from distal to proximal segments along vascular walls. Pries et al. formulated a theoretical model involving these four local stimuli to simulate long-term changes of vessel diameters during structural adaption of microvascular networks. Here we apply this vessel adaptation algorithm to synthetic arteriovenous blood vessel networks generated by our simulation framework “Tumorcode”. We fixed the free model parameters by an optimization method combined with the requirement of homogeneous flow in the capillary bed. We find that the local blood volume, surface to volume ratio and branching ratio differs from networks with radii fulfilling Murray’s law exactly to networks with radii obtained by the adaptation algorithm although their relation is close to Murray’s law. |
DOI der Erstveröffentlichung: | 10.1016/j.jtbi.2019.109989 |
URL der Erstveröffentlichung: | https://www.sciencedirect.com/science/article/abs/pii/S0022519319303406 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-376118 hdl:20.500.11880/34025 http://dx.doi.org/10.22028/D291-37611 |
ISSN: | 0022-5193 |
Datum des Eintrags: | 14-Okt-2022 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Physik |
Professur: | NT - Prof. Dr. Heiko Rieger |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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