Please use this identifier to cite or link to this item: doi:10.22028/D291-37442
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Title: Chemical composition and biological activities of Valeriana dioscoridis SM. roots
Author(s): Sen-Utsukarci, Burcu
Kessler, Sonja M.
Akbal-Dagistan, Ozlem
Estep, Alden S.
Tabanca, Nurhayat
Kurkcuoglu, Mine
Demirci-Kayiran, Serpil
Eroglu-Ozkan, Esra
Gul, Zulfiye
Bardakci, Hilal
Becnel, James
Kiemer, Alexandra K.
Mat, Afife
Baser, Kemal Husnu Can
Language: English
Title: South African Journal of Botany
Volume: 141
Pages: 306-312
Publisher/Platform: Elsevier
Year of Publication: 2021
Free key words: Valeriana dioscoridis
Insect repellent
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Zika, dengue, and Yellow fever are transmitted primarily by Aedes aegypti mosquitoes. Investigations to find more natural but highly effective pesticidal agents against Ae. aegypti have increased in the last few years. Plant-based compounds have been the source of several current pesticides and have provided models for creation of synthetic derivatives like the pyrethroids. Plants continue to be a rich source for potential new active ingredients. The aim of this study is to increase knowledge on V. dioscoridis and to present the results of the cytotoxic and insecticidal activities of various extracts of its roots and volatile compound compositions of roots. The hexane and chloroform extracts, HM1 and CM1 respectively, exhibited cytotoxicity with IC50 values of 128.4 and 86.93 µg/mL against the HepG2 cell line. Because CM1 had higher cytotoxicity across the studied concentration range, it was also tested against the HUVEC cell line. Extracts HM1 and CM1 were also tested for their insecticidal activities. CM1 was found to be the more active (mortality (%) = 96.7% ± 5.8 at 5 μg/mosquito), consistent with its cytotoxic activity. Since these active extracts were nonpolar, the chemical composition of the volatile compounds of the roots were analyzed by GC-MS analysis. About 87.7% of the essential oil were characterized. The major compound was ß-eudesmol (9.2%), following by camphene (8.9%), bornyl acetate (8.2%) and maaliol (7.6%). This is the first study on the HepG2 and HUVEC cytotoxicity and insecticidal activity of V. dioscoridis. Further studies on the potential of this plant to define the spectrum of activity and examine potential therapeutic agents is warranted.
DOI of the first publication: 10.1016/j.sajb.2021.05.007
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-374425
ISSN: 0254-6299
Date of registration: 29-Sep-2022
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Alexandra K. Kiemer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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