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doi:10.22028/D291-37176
Titel: | Primary Staging of Prostate Cancer Patients with [18F]PSMA-1007 PET/CT Compared with [68Ga]Ga-PSMA-11 PET/CT |
VerfasserIn: | Hoffmann, Manuela A. Müller-Hübenthal, Jonas Rosar, Florian Fischer, Nicolas von Eyben, Finn Edler Buchholz, Hans-Georg Wieler, Helmut J. Schreckenberger, Mathias |
Sprache: | Englisch |
Titel: | Journal of Clinical Medicine |
Bandnummer: | 11 |
Heft: | 17 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | PSMA hybrid imaging staging of primary prostate cancer [18F]PSMA-1007 [68Ga]GaPSMA-11 SUVmax cut-off level prostate carcinoma |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Hybrid imaging with prostate-specific membrane antigen (PSMA) is gaining importance as an increasingly meaningful tool for prostate cancer (PC) diagnostics and as a guide for therapy decisions. This study aims to investigate and compare the performance of [18F]PSMA1007 (18F-PSMA) and [68Ga]Ga-PSMA-11 positron emission tomography/computed tomography ( 68Ga-PSMA) in the initial staging of PC patients. Methods: The data of 88 biopsy-proven patients were retrospectively evaluated. PSMA-avid lesions were compared with the histopathologic Gleason Score (GS) for prostate biopsies, and the results were plotted by receiver operating characteristic (ROC)-curve. Optimal maximum standardized uptake value (SUVmax) cut-off values were rated using the Youden index. Results: 18F-PSMA was able to distinguish GS ≤ 7a from ≥7b with a sensitivity of 62%, specificity of 85%, positive predictive value (PPV) of 92%, and accuracy of 67% for a SUVmax of 8.95, whereas sensitivity was 54%, specificity 91%, PPV 93%, and accuracy 66% for 68Ga-PSMA (SUVmax 8.7). Conclusions: Both methods demonstrated a high concordance of detected PSMA-avid lesions with histopathologically proven PC. 18F-PSMA and 68Ga-PSMA are both suitable for the characterization of primary PC with a comparable correlation of PSMA-avid lesions with GS. Neither method showed a superior advantage. Our calculated SUVmax thresholds may represent valuable parameters in clinical use to distinguish clinically significant PC (csPC) from non-csPC. |
DOI der Erstveröffentlichung: | 10.3390/jcm11175064 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-371763 hdl:20.500.11880/33731 http://dx.doi.org/10.22028/D291-37176 |
ISSN: | 2077-0383 |
Datum des Eintrags: | 12-Sep-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Radiologie |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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jcm-11-05064.pdf | 2,33 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons