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doi:10.22028/D291-37133
Titel: | Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/β-catenin signaling |
VerfasserIn: | Ji, Ping Zhou, Yongxin Yang, Yibao Wu, Junlu Zhou, Hao Quan, Wenqiang Sun, Junjun Yao, Yiwen Shang, Anquan Gu, Chenzheng Zeng, Bingjie Firrman, Jenni Xiao, Weidong Bals, Robert Sun, Zujun Li, Dong |
Sprache: | Englisch |
Titel: | Theranostics |
Bandnummer: | 9 |
Heft: | 8 |
Seiten: | 2209-2223 |
Verlag/Plattform: | Ivyspring |
Erscheinungsjahr: | 2019 |
Freie Schlagwörter: | LL-37 lung cancer tumor microenvironment Wnt/β-catenin |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Rationale: Antimicrobial peptides, such as cathelicidin LL-37/hCAP-18, are important effectors of the innate immune system with direct antibacterial activity. In addition, LL-37 is involved in the regulation of tumor cell growth. However, the molecular mechanisms underlying the functions of LL-37 in promoting lung cancer are not fully understood. Methods: The expression of LL-37 in the tissues and sera of patients with non-small cell lung cancer was determined through immunohistological, immunofluorescence analysis, and enzyme-linked immunosorbent assay. The animal model of wild-type and Cramp knockout mice was employed to evaluate the tumorigenic effect of LL-37 in non-small cell lung cancer. The mechanism of LL-37 involving in the promotion of lung tumor growth was evaluated via microarray analyses, recombinant protein treatment approaches in vitro, tumor immunohistochemical assays, and intervention studies in vivo. Results: LL-37 produced by myeloid cells was frequently upregulated in primary human lung cancer tissues. Moreover, its expression level correlated with poor clinical outcome. LL-37 activated Wnt/β-catenin signaling by inducing the phosphorylation of protein kinase B and subsequent phosphorylation of glycogen synthase kinase 3β mediated by the toll-like receptor-4 expressed in lung tumor cells. LL-37 treatment of tumor cells also decreased the levels of Axin2. In contrast, it elevated those of an RNA-binding protein (tristetraprolin), which may be involved in the mechanism through which LL-37 induces activation of Wnt/β-catenin. Conclusion: LL-37 may be a critical molecular link between tumor-supportive immune cells and tumors, facilitating the progression of lung cancer. |
DOI der Erstveröffentlichung: | 10.7150/thno.30726 |
URL der Erstveröffentlichung: | https://www.thno.org/v09p2209.htm |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-371339 hdl:20.500.11880/33700 http://dx.doi.org/10.22028/D291-37133 |
ISSN: | 1838-7640 |
Datum des Eintrags: | 1-Sep-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Material |
In Beziehung stehendes Objekt: | http://www.thno.org/v09p2209s1.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin M - Neurologie und Psychiatrie |
Professur: | M - Prof. Dr. Robert Bals M - Prof. Dr. Klaus Faßbender |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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v09p2209.pdf | 3,98 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons