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Titel: Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/β-catenin signaling
VerfasserIn: Ji, Ping
Zhou, Yongxin
Yang, Yibao
Wu, Junlu
Zhou, Hao
Quan, Wenqiang
Sun, Junjun
Yao, Yiwen
Shang, Anquan
Gu, Chenzheng
Zeng, Bingjie
Firrman, Jenni
Xiao, Weidong
Bals, Robert
Sun, Zujun
Li, Dong
Sprache: Englisch
Titel: Theranostics
Bandnummer: 9
Heft: 8
Seiten: 2209-2223
Verlag/Plattform: Ivyspring
Erscheinungsjahr: 2019
Freie Schlagwörter: LL-37
lung cancer
tumor microenvironment
Wnt/β-catenin
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Rationale: Antimicrobial peptides, such as cathelicidin LL-37/hCAP-18, are important effectors of the innate immune system with direct antibacterial activity. In addition, LL-37 is involved in the regulation of tumor cell growth. However, the molecular mechanisms underlying the functions of LL-37 in promoting lung cancer are not fully understood. Methods: The expression of LL-37 in the tissues and sera of patients with non-small cell lung cancer was determined through immunohistological, immunofluorescence analysis, and enzyme-linked immunosorbent assay. The animal model of wild-type and Cramp knockout mice was employed to evaluate the tumorigenic effect of LL-37 in non-small cell lung cancer. The mechanism of LL-37 involving in the promotion of lung tumor growth was evaluated via microarray analyses, recombinant protein treatment approaches in vitro, tumor immunohistochemical assays, and intervention studies in vivo. Results: LL-37 produced by myeloid cells was frequently upregulated in primary human lung cancer tissues. Moreover, its expression level correlated with poor clinical outcome. LL-37 activated Wnt/β-catenin signaling by inducing the phosphorylation of protein kinase B and subsequent phosphorylation of glycogen synthase kinase 3β mediated by the toll-like receptor-4 expressed in lung tumor cells. LL-37 treatment of tumor cells also decreased the levels of Axin2. In contrast, it elevated those of an RNA-binding protein (tristetraprolin), which may be involved in the mechanism through which LL-37 induces activation of Wnt/β-catenin. Conclusion: LL-37 may be a critical molecular link between tumor-supportive immune cells and tumors, facilitating the progression of lung cancer.
DOI der Erstveröffentlichung: 10.7150/thno.30726
URL der Erstveröffentlichung: https://www.thno.org/v09p2209.htm
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-371339
hdl:20.500.11880/33700
http://dx.doi.org/10.22028/D291-37133
ISSN: 1838-7640
Datum des Eintrags: 1-Sep-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: http://www.thno.org/v09p2209s1.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
M - Neurologie und Psychiatrie
Professur: M - Prof. Dr. Robert Bals
M - Prof. Dr. Klaus Faßbender
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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