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doi:10.22028/D291-37091
Titel: | Vena Cava Thrombus in Patients with Wilms Tumor |
VerfasserIn: | Meier, Clemens-Magnus Furtwängler, Rhoikos von Schweinitz, Dietrich Stein, Raimund Welter, Nils Wagenpfeil, Stefan Kager, Leo Schenk, Jens-Peter Vokuhl, Christian Melchior, Patrick Fuchs, Jörg Graf, Norbert |
Sprache: | Englisch |
Titel: | Cancers |
Bandnummer: | 14 |
Heft: | 16 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Wilms tumor treatment surgery preoperative chemotherapy vena cava thrombus |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | (1) Background: Vena cava thrombus (VCT) is rare in Wilms tumor (WT) (4–10%). The aim of this study is to identify factors for an outcome to improve treatment for better survival. (2) Methods: 148/3015 patients with WT (aged < 18 years) and VCT, prospectively enrolled over a period of 32 years (1989–2020) by the German Society for Pediatric Oncology and Hematology (SIOP-9/GPOH, SIOP-93-01/GPOH and SIOP-2001/GPOH), are retrospectively analyzed to describe clinical features, response to preoperative chemotherapy (PC) (142 patients) and surgical interventions and to evaluate risk factors for overall survival (OS). (3) Results: 14 VCT regressed completely with PC and another 12 in parts. The thrombus was completely removed in 111 (85.4%), incompletely in 16 (12.3%), and not removed in 3 (2.3%). The type of removal is unknown in four patients. Patients without VCT have a significantly (p < 0.001) better OS (97.8%) than those with VCT (90.1%). OS after complete resection is (89.9%), after incomplete (93.8%) and with no resection (100%). Patients with anaplasia or stage IV without complete remission (CR) after PC had a significantly worse OS compared to the remaining patients with VCT (77.1% vs. 94.4%; p = 0.002). (4) Conclusions: As a result of our study, two risk factors for poor outcomes in WT patients with VCT emerge: diffuse anaplasia and metastatic disease, especially those with non-CR after PC. |
DOI der Erstveröffentlichung: | 10.3390/cancers14163924 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-370911 hdl:20.500.11880/33682 http://dx.doi.org/10.22028/D291-37091 |
ISSN: | 2072-6694 |
Datum des Eintrags: | 29-Aug-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Materials |
In Beziehung stehendes Objekt: | https://www.mdpi.com/article/10.3390/cancers14163924/s1 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Chirurgie M - Medizinische Biometrie, Epidemiologie und medizinische Informatik M - Pädiatrie M - Radiologie |
Professur: | M - Prof. Dr. Norbert Graf M - Prof. Dr. Stefan Wagenpfeil M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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cancers-14-03924.pdf | 1,18 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons