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Titel: Vena Cava Thrombus in Patients with Wilms Tumor
VerfasserIn: Meier, Clemens-Magnus
Furtwängler, Rhoikos
von Schweinitz, Dietrich
Stein, Raimund
Welter, Nils
Wagenpfeil, Stefan
Kager, Leo
Schenk, Jens-Peter
Vokuhl, Christian
Melchior, Patrick
Fuchs, Jörg
Graf, Norbert
Sprache: Englisch
Titel: Cancers
Bandnummer: 14
Heft: 16
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: Wilms tumor
treatment
surgery
preoperative chemotherapy
vena cava thrombus
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: (1) Background: Vena cava thrombus (VCT) is rare in Wilms tumor (WT) (4–10%). The aim of this study is to identify factors for an outcome to improve treatment for better survival. (2) Methods: 148/3015 patients with WT (aged < 18 years) and VCT, prospectively enrolled over a period of 32 years (1989–2020) by the German Society for Pediatric Oncology and Hematology (SIOP-9/GPOH, SIOP-93-01/GPOH and SIOP-2001/GPOH), are retrospectively analyzed to describe clinical features, response to preoperative chemotherapy (PC) (142 patients) and surgical interventions and to evaluate risk factors for overall survival (OS). (3) Results: 14 VCT regressed completely with PC and another 12 in parts. The thrombus was completely removed in 111 (85.4%), incompletely in 16 (12.3%), and not removed in 3 (2.3%). The type of removal is unknown in four patients. Patients without VCT have a significantly (p < 0.001) better OS (97.8%) than those with VCT (90.1%). OS after complete resection is (89.9%), after incomplete (93.8%) and with no resection (100%). Patients with anaplasia or stage IV without complete remission (CR) after PC had a significantly worse OS compared to the remaining patients with VCT (77.1% vs. 94.4%; p = 0.002). (4) Conclusions: As a result of our study, two risk factors for poor outcomes in WT patients with VCT emerge: diffuse anaplasia and metastatic disease, especially those with non-CR after PC.
DOI der Erstveröffentlichung: 10.3390/cancers14163924
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-370911
hdl:20.500.11880/33682
http://dx.doi.org/10.22028/D291-37091
ISSN: 2072-6694
Datum des Eintrags: 29-Aug-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/cancers14163924/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
M - Pädiatrie
M - Radiologie
Professur: M - Prof. Dr. Norbert Graf
M - Prof. Dr. Stefan Wagenpfeil
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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