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doi:10.22028/D291-37084
Titel: | MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome |
VerfasserIn: | Abu-Halima, Masood Oberhoffer, Felix Sebastian Wagner, Viktoria Abd El Rahman, Mohamed Jung, Anna-Maria Zemlin, Michael Rohrer, Tilman R. Meese, Eckart Abdul-Khaliq, Hashim |
Sprache: | Englisch |
Titel: | Children |
Bandnummer: | 9 |
Heft: | 8 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Turner Syndrome MicroRNAs vascular dysfunction |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Turner Syndrome (TS) is a relatively rare X-chromosomal disease with increased cardiovascular morbidity and mortality. This study aimed to identify whether the circulating miR-126-3p/5p are involved in the pathophysiology of vascular dysfunction in TS. Methods: Using the RT-qPCR, the abundance levels of miR-126-3p and miR-126-5p were determined in 33 TS patients and 33 age-matched healthy volunteers (HVs). Vascular screening, including the assessment of blood pressure, pulse wave velocity, augmentation index, aortic deformation, arterial distensibility, and arterial elastance, was conducted in TS patients and HVs. Results: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs (p < 0.0001). Within the TS cohort, miR-126-3p/5p correlated significantly with aortic deformation (r = 0.47, p = 0.01; r = 0.48, p < 0.01) and arterial distensibility (r = 0.55, p < 0.01; r = 0.48, p < 0.01). In addition, a significant negative correlation was demonstrated between miR-126-3p and arterial elastance (r = −0.48, p = 0.01). The receiver operating characteristic analysis showed that miR-126-3p and miR-126-5p separated the tested groups with high sensitivity and specificity. Conclusions: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs. Within the TS cohort, a lower abundance level of miR-126-3p and miR-126-5p was linked with a significantly higher aortic stiffness. |
DOI der Erstveröffentlichung: | 10.3390/children9081109 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-370847 hdl:20.500.11880/33665 http://dx.doi.org/10.22028/D291-37084 |
ISSN: | 2227-9067 |
Datum des Eintrags: | 26-Aug-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Humangenetik M - Medizinische Biometrie, Epidemiologie und medizinische Informatik M - Pädiatrie |
Professur: | M - Prof. Dr. Hashim Abdul-Khaliq M - Prof. Dr. Eckhart Meese M - Prof. Dr. Michael Zemlin M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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children-09-01109-v2.pdf | 1,28 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons