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Titel: Alzheimer's Disease Composite Score: A Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer's Disease
VerfasserIn: Hendrix, Suzanne B.
Soininen, Hilkka
van Hees, Anneke M. J.
Ellison, Noel
Visser, Pieter Jelle
Solomon, Alina
Attali, A.
Blennow, Kay
Kivipelto, Miia
Hartmann, Tobias UdsID
Sprache: Englisch
In:
Titel: The journal of prevention of Alzheimer's disease : JPAD
Bandnummer: 6
Heft: 4
Startseite: 232
Endseite: 236
Verlag/Plattform: Springer
Erscheinungsjahr: 2019
Freie Schlagwörter: Alzheimer’s disease
prodromal
cognitive function
nutrients
Souvenaid
Fortasyn
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: As research evolves in prodromal AD, the need to validate sufficiently sensitive outcome measures, e.g. the Alzheimer's Disease Composite Score (ADCOMS) is clear. In the LipiDiDiet randomized trial in prodromal AD, cognitive decline in the study population was much less than expected in the timeframe studied. While the primary composite endpoint was insufficiently sensitive to detect a difference in the modified intention to treat population, the per-protocol population showed less decline in the active than the control group, indicating better treatment effects with regular product intake. These results were further strengthened by significant benefits on secondary endpoints of cognition and function, and brain atrophy. The present post-hoc analysis investigated whether ADCOMS could detect a difference between groups in the LipiDiDiet population (138 active, 140 control). The estimated mean change in ADCOMS from baseline (standard error) was 0.085 (0.018) in the active and 0.133 (0.018) in the control group; estimated mean treatment difference -0.048 (95% confidence intervals -0.090, -0.007; p=0.023), or 36% less decline in the active group. This suggests ADCOMS identified the cognitive and functional benefits observed previously, confirming the sensitivity of this composite measure.
DOI der Erstveröffentlichung: 10.14283/jpad.2019.33
URL der Erstveröffentlichung: https://link.springer.com/article/10.14283/jpad.2019.33
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-370008
hdl:20.500.11880/33593
http://dx.doi.org/10.22028/D291-37000
ISSN: 2426-0266
2274-5807
Datum des Eintrags: 8-Aug-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Neurologie und Psychiatrie
Professur: M - Prof. Dr. Tobias Hartmann
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



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