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doi:10.22028/D291-36849
Titel: | Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk |
VerfasserIn: | Haring, Bernhard Wissel, Stephanie Manson, JoAnn E. |
Sprache: | Englisch |
Titel: | Current Cardiology Reports |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Somatic mutations Clonal hematopoiesis of indeterminate potential Age-related cardiovascular risk Preventive cardiology |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Purpose of Review Clonal hematopoiesis of indeterminate potential (CHIP) has been identifed as a novel cardiovascular risk factor. Here we review the relationship of lifestyle and environmental risk factors predisposing to somatic mutations and CHIP and provide an overview on age-related cardiovascular outcomes. Recent Findings CHIP has been associated with accelerated atherosclerosis and cardiovascular disease in both epidemiologi cal and experimental studies. The most commonly mutated candidate driver genes are DNMT3A, TET2, JAK2, and ASXL1. The underlying mechanisms appear predominantly related to infammatory pathways. Although age is the dominant risk factor for developing CHIP, emerging evidence suggests that other factors such as smoking, obesity/type 2 diabetes, or an unhealthy diet play a role in the occurrence of somatic mutations. Summary Evidence suggests a strong link between vascular risk factors, somatic hematopoietic mutations, and age-related cardiovascular disease. Further studies on CHIP biology are required to identify targeted interventions for risk reduction in patients with CHIP and inform the utility of screening strategies. |
DOI der Erstveröffentlichung: | 10.1007/s11886-022-01724-2 |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s11886-022-01724-2 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-368497 hdl:20.500.11880/33476 http://dx.doi.org/10.22028/D291-36849 |
ISSN: | 1534-3170 1523-3782 |
Datum des Eintrags: | 18-Jul-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Haring2022_Article_SomaticMutationsAndClonalHemat.pdf | 1,61 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons