Please use this identifier to cite or link to this item: doi:10.22028/D291-36849
Title: Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk
Author(s): Haring, Bernhard
Wissel, Stephanie
Manson, JoAnn E.
Language: English
Title: Current Cardiology Reports
Publisher/Platform: Springer Nature
Year of Publication: 2022
Free key words: Somatic mutations
Clonal hematopoiesis of indeterminate potential
Age-related cardiovascular risk
Preventive cardiology
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Purpose of Review Clonal hematopoiesis of indeterminate potential (CHIP) has been identifed as a novel cardiovascular risk factor. Here we review the relationship of lifestyle and environmental risk factors predisposing to somatic mutations and CHIP and provide an overview on age-related cardiovascular outcomes. Recent Findings CHIP has been associated with accelerated atherosclerosis and cardiovascular disease in both epidemiologi cal and experimental studies. The most commonly mutated candidate driver genes are DNMT3A, TET2, JAK2, and ASXL1. The underlying mechanisms appear predominantly related to infammatory pathways. Although age is the dominant risk factor for developing CHIP, emerging evidence suggests that other factors such as smoking, obesity/type 2 diabetes, or an unhealthy diet play a role in the occurrence of somatic mutations. Summary Evidence suggests a strong link between vascular risk factors, somatic hematopoietic mutations, and age-related cardiovascular disease. Further studies on CHIP biology are required to identify targeted interventions for risk reduction in patients with CHIP and inform the utility of screening strategies.
DOI of the first publication: 10.1007/s11886-022-01724-2
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-368497
ISSN: 1534-3170
Date of registration: 18-Jul-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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