Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-36781
Volltext verfügbar? / Dokumentlieferung
Titel: Relationship between clinical and radiological signs of bronchiectasis in COPD patients : Results from COSYCONET
VerfasserIn: Kahnert, Kathrin
Jörres, Rudolf A.
Kauczor, Hans-Ulrich
Biederer, Jürgen
Jobst, Bertram
Alter, Peter
Biertz, Frank
Mertsch, Pontus
Lucke, Tanja
Lutter, Johanna I.
Trudzinski, Franziska C.
Behr, Jürgen
Bals, Robert
Watz, Henrik
Vogelmeier, Claus F.
Welte, Tobias
Sprache: Englisch
Titel: Respiratory Medicine
Bandnummer: 172
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2020
Freie Schlagwörter: COPD
Bronchiectasis
CT scan
Lung function
Symptoms
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Bronchiectasis (BE) might be frequently present in COPD but masked by COPD symptoms. We studied the relationship of clinical signs of bronchiectasis to the presence and extent of its radiological signs in patients of different COPD severity. Visit 4 data (GOLD grades 1–4) of the COSYCONET cohort was used. Chest CT scans were evaluated for bronchiectasis in 6 lobes using a 3-point scale (0: absence, 1: ≤50%, 2: >50% BE-involvement for each lobe). 1176 patients were included (61%male, age 67.3y), among them 38 (3.2%) with reported physicians’ diagnosis of bronchiectasis and 76 (6.5%) with alpha1-antitrypsin deficiency (AA1D). CT scans were obtained in 429 patients. Within this group, any signs of bronchiectasis were found in 46.6% of patients, whereby ≤50% BE occurred in 18.6% in ≤2 lobes, in 10.0% in 3–4 lobes, in 15.9% in 5–6 lobes; >50% bronchiectasis in at least 1 lobe was observed in 2.1%. Scores ≥4 correlated with an elevated ratio FRC/RV. The clinical diagnosis of bronchiectasis correlated with phlegm and cough and with radiological scores of at least 3, optimally ≥5. In COPD patients, clinical diagnosis and radiological signs of BE showed only weak correlations. Correlations became significant with increasing BE-severity implying radiological alterations in several lobes. This indicates the importance of reporting both presence and extent of bronchiectasis on CT. Further research is warranted to refine the criteria for CT scoring of bronchiectasis and to determine the relevance of radiologically but not clinically detectible bronchiectasis and their possible implications for therapy in COPD patients.
DOI der Erstveröffentlichung: 10.1016/j.rmed.2020.106117
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/abs/pii/S0954611120302572
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-367817
hdl:20.500.11880/33418
http://dx.doi.org/10.22028/D291-36781
ISSN: 0954-6111
Datum des Eintrags: 12-Jul-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Es gibt keine Dateien zu dieser Ressource.


Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt.