Please use this identifier to cite or link to this item: doi:10.22028/D291-36758
Title: COPD maintenance medication is linked to left atrial size: Results from the COSYCONET cohort
Author(s): Kellerer, Christina
Kahnert, Kathrin
Trudzinski, Franziska C.
Lutter, Johanna
Berschneider, Korbinian
Speicher, Tim
Watz, Henrik
Bals, Robert
Welte, Tobias
Vogelmeier, Claus F.
Jörres, Rudolf A.
Alter, Peter
Language: English
Title: Respiratory Medicine
Volume: 185
Publisher/Platform: Elsevier
Year of Publication: 2021
Free key words: COPD
Maintenance medication
ICS
LABA
LAMA
Cardiac size
Left atrium
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background: Lung function impairment in COPD is known to be related to reductions of left heart size, while short-term interventional trials with bronchodilators showed positive effects on cardiac parameters. We investigated whether COPD maintenance therapy has analogous long-term effects. Methods: Pooled data of GOLD grade 1–4 patients from visits 1 and 3 (1.5 y apart) of the COSYCONET cohort were used. Medication was categorized as use of ICS, LABA + ICS, LABA + LAMA and triple therapy (LABA + LAMA + ICS), contrasting “always” versus “never”. Echocardiographic parameters comprised left ventricular end-diastolic and -systolic diameter (LVEDD, LVESD), ejection fraction (LVEF) and left atrial diameter (LA). Associations were identified by multiple regression analysis, as well as propensity score analysis. Results: Overall, 846 patients (mean age 64.5 y; 41% female) were included, 53% using ICS at both visits, 51% LABA + ICS, 56% LABA + LAMA, 40% LABA + LAMA + ICS (triple) therapy. Conversely, 30%, 32%, 28% and 42% had no ICS, LABA + ICS, LABA + LAMA or triple therapy, respectively, at both visits. Among echocardiographic measures, only LA showed statistically significant associations (increases) with medication, whereby significant effects were linked to ICS, LABA + ICS and LABA + LAMA (p < 0.05 each, “always” versus “never”) and propensity score analyses underlined the role of LABA + LAMA. Conclusions: In this observational study, COPD maintenance therapy, especially LABA + LAMA, was linked to left atrial size, consistent with the results of short-term interventional trials. These findings suggest that maintenance medication for COPD does not only improve lung function and patient reported outcomes but may also have an impact on the cardiovascular system.
DOI of the first publication: 10.1016/j.rmed.2021.106461
URL of the first publication: https://www.sciencedirect.com/science/article/pii/S0954611121001670?via%3Dihub
Link to this record: urn:nbn:de:bsz:291--ds-367587
hdl:20.500.11880/33400
http://dx.doi.org/10.22028/D291-36758
ISSN: 0954-6111
Date of registration: 11-Jul-2022
Description of the related object: Supplementary data
Related object: https://ars.els-cdn.com/content/image/1-s2.0-S0954611121001670-mmc1.pdf
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Robert Bals
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
1-s2.0-S0954611121001670-main.pdf807,17 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons