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doi:10.22028/D291-36726
Titel: | Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities |
VerfasserIn: | Trudzinski, Franziska C. Kellerer, Christina Jörres, Rudolf A. Alter, Peter Lutter, Johanna I Trinkmann, Frederik Herth, Felix J. F. Frankenberger, Marion Watz, Henrik Vogelmeier, Claus F Kauczor, Hans-Ulrich Welte, Tobias Behr, Jürgen Bals, Robert Kahnert, Kathrin |
Sprache: | Englisch |
Titel: | Clinical Research in Cardiology |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | COPD Gender COPD assessment test Cardiac comorbidities Symptoms |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background In chronic obstructive pulmonary disease (COPD), gender-specifc diferences in the prevalence of symptoms and comorbidity are known. Research question We studied whether the relationship between these characteristics depended on gender and carried diag nostic information regarding cardiac comorbidities. Study design and methods The analysis was based on 2046 patients (GOLD grades 1–4, 795 women; 38.8%) from the COSYCONET COPD cohort. Assessments comprised the determination of clinical history, comorbidities, lung function, COPD Assessment Test (CAT) and modifed Medical Research Council dyspnea scale (mMRC). Using multivariate regres sion analyses, gender-specifc diferences in the relationship between symptoms, single CAT items, comorbidities and functional alterations were determined. To reveal the relationship to cardiac disease (myocardial infarction, or heart failure, or coronary artery disease) logistic regression analysis was performed separately in men and women. Results Most functional parameters and comorbidities, as well as CAT items 1 (cough), 2 (phlegm) and 5 (activities), dif fered signifcantly (p<0.05) between men and women. Beyond this, the relationship between functional parameters and comorbidities versus symptoms showed gender-specifc diferences, especially for single CAT items. In men, item 8 (energy), mMRC, smoking status, BMI, age and spirometric lung function was related to cardiac disease, while in women primarily age was predictive. Interpretation Gender-specifc diferences in COPD not only comprised diferences in symptoms, comorbidities and func tional alterations, but also diferences in their mutual relationships. This was refected in diferent determinants linked to cardiac disease, thereby indicating that simple diagnostic information might be used diferently in men and women. Clinical trial registration The cohort study is registered on ClinicalTrials.gov with identifer NCT01245933 and on Ger manCTR.de with identifer DRKS00000284, date of registration November 23, 2010. Further information can be obtained on the website http://www.asconet.net. |
DOI der Erstveröffentlichung: | 10.1007/s00392-021-01915-x |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s00392-021-01915-x |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-367263 hdl:20.500.11880/33370 http://dx.doi.org/10.22028/D291-36726 |
ISSN: | 1861-0692 1861-0684 |
Datum des Eintrags: | 8-Jul-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1007%2Fs00392-021-01915-x/MediaObjects/392_2021_1915_MOESM1_ESM.docx https://static-content.springer.com/esm/art%3A10.1007%2Fs00392-021-01915-x/MediaObjects/392_2021_1915_MOESM2_ESM.docx https://static-content.springer.com/esm/art%3A10.1007%2Fs00392-021-01915-x/MediaObjects/392_2021_1915_MOESM3_ESM.tif |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Robert Bals |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Trudzinski2021_Article_Gender-specificDifferencesInCO.pdf | 1,01 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons