Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
doi:10.22028/D291-36716
Titel: | IgE is associated with exacerbations and lung function decline in COPD |
VerfasserIn: | Lommatzsch, Marek Speer, Timotheus Herr, Christian Jörres, Rudolf A. Watz, Henrik Müller, Achim Welte, Tobias Vogelmeier, Claus F. Bals, Robert |
Sprache: | Englisch |
Titel: | Respiratory Research |
Bandnummer: | 23 |
Heft: | 1 |
Verlag/Plattform: | BMC |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | COPD IgE Exacerbations Lung function decline |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Both allergen-specifc IgE and total IgE in serum play a major role in asthma. However, the role of IgE in chronic obstructive pulmonary disease (COPD) is poorly understood. It was the aim of this study to systematically analyze the relationship between serum IgE levels and disease characteristics in large COPD cohorts. Methods: COSYCONET is a comprehensively characterized cohort of patients with COPD: total IgE and IgE specifc to common aeroallergens were measured in serum of 2280 patients, and related to clinical characteristics of the patients. WISDOM is another large COPD population (2477 patients): this database contains the information whether total IgE in serum was elevated (≥100 IU/l) or normal in patients with COPD. Results: Both in COSYCONET and WISDOM, total IgE was elevated (≥100 IU/l) in>30% of the patients, higher in men than in women, and higher in currently than in not currently smoking men. In COSYCONET, total IgE was elevated in patients with a history of asthma and/or allergies. Men with at least one exacerbation in the last 12 months (50.6% of all men in COSYCONET) had higher median total IgE (71.3 IU/l) than men without exacerbations (48.3 IU/l): this diference was also observed in the subgroups of not currently smoking men and of men without a history of asthma. Surprisingly, a history of exacerbations did not impact on total IgE in women with COPD. Patients in the highest ter tiles of total IgE (>91.5 IU/ml, adjusted OR: 1.62, 95% CI 1.12–2.34) or allergen-specifc IgE (>0.19 IU/ml, adjusted OR: 2.15, 95% CI 1.32–3.51) were at risk of lung function decline (adjusted by: age, gender, body mass index, initial lung function, smoking status, history of asthma, history of allergy). Conclusion: These data suggest that IgE may play a role in specifc COPD subgroups. Clinical trials using antibodies targeting the IgE pathway (such as omalizumab), especially in men with recurrent exacerbations and elevated serum IgE, could elucidate potential therapeutic implications of our observations. |
DOI der Erstveröffentlichung: | 10.1186/s12931-021-01847-0 |
URL der Erstveröffentlichung: | https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-021-01847-0 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-367166 hdl:20.500.11880/33361 http://dx.doi.org/10.22028/D291-36716 |
ISSN: | 1465-993X |
Datum des Eintrags: | 8-Jul-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-021-01847-0/MediaObjects/12931_2021_1847_MOESM1_ESM.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Robert Bals M - Dr. med. Dr. sc.nat. Timo Speer |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
s12931-021-01847-0.pdf | 1,49 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons