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doi:10.22028/D291-36713
Titel: | Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment |
VerfasserIn: | Kahnert, Kathrin Andreas, Stefan Kellerer, Christina Lutter, Johanna I. Lucke, Tanja Yildirim, Önder Lehmann, Mareike Seissler, Jochen Behr, Jürgen Frankenberger, Marion Bals, Robert Watz, Henrik Welte, Tobias Trudzinski, Franziska C. Vogelmeier, Claus F. Alter, Peter Jörres, Rudolf A. |
Sprache: | Englisch |
Titel: | Scientific Reports |
Bandnummer: | 12 |
Heft: | 1 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Drug therapy Epidemiology |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging efects of metformin. Patients of GOLD grades 1–4 of the COSYCONET cohort with follow-up data of up to 4.5 y were included. The annual decline in lung function (FEV1, FVC) and CO difusing capacity (KCO, TLCO) in %predicted at baseline was evaluated for associations with age, sex, BMI, pack-years, smoking status, baseline lung function, exacerbation risk, respiratory symptoms, cardiac disease, as well as metformin-containing therapy compared to patients without diabetes and metformin. Among 2741 patients, 1541 (mean age 64.4 y, 601 female) fulflled the inclusion criteria. In the group with metformin treatment vs. non-diabetes the mean annual decline in KCO and TLCO was signifcantly lower (0.2 vs 2.3, 0.8 vs. 2.8%predicted, respectively; p < 0.05 each), but not the decline of FEV1 and FVC. These results were confrmed using multiple regression and propensity score analyses. Our fndings demonstrate an association between the annual decline of lung difusing capacity and the intake of metformin in patients with COPD consistent with the hypothesis of anti-aging efects of metformin as refected in a surrogate marker of emphysema. |
DOI der Erstveröffentlichung: | 10.1038/s41598-022-05276-x |
URL der Erstveröffentlichung: | https://www.nature.com/articles/s41598-022-05276-x |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-367134 hdl:20.500.11880/33356 http://dx.doi.org/10.22028/D291-36713 |
ISSN: | 2045-2322 |
Datum des Eintrags: | 8-Jul-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-022-05276-x/MediaObjects/41598_2022_5276_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-022-05276-x/MediaObjects/41598_2022_5276_MOESM2_ESM.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Robert Bals |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s41598-022-05276-x.pdf | 1,29 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons