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Titel: Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease : results from COSYCONET
VerfasserIn: Trudzinski, Franziska C.
Jörres, Rudolf A.
Alter, Peter
Walter, Julia
Watz, Henrik
Koch, Andrea
John, Matthias
Lommatzsch, Marek
Vogelmeier, Claus F.
Kauczor, Hans-Ulrich
Welte, Tobias
Behr, Jürgen
Tufman, Amanda
Bals, Robert UdsID
Herth, Felix J. F.
Kahnert, Kathrin
Sprache: Englisch
In:
Titel: Scientific Reports
Bandnummer: 12
Heft: 1
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2022
Freie Schlagwörter: Medical research
Prognosis
Respiratory tract diseases
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: In patients with COPD, it has not been comprehensively assessed whether the predictive value of comorbidities for mortality difers between men and women. We therefore aimed to examine sex diferences of COPD comorbidities in regard with prognosis by classifying comorbidities into a comorbidome related to extrapulmonary disorders and a pulmorbidome, referring to pulmonary disorders. The study population comprised 1044 women and 1531 men with the diagnosis of COPD from COSYCONET, among them 2175 of GOLD grades 1–4 and 400 at risk. Associations of comorbidities with mortality were studied using Cox regression analysis for men and women separately. During the follow-up (median 3.7 years) 59 women and 159 men died. In men, obesity, hypertension, coronary artery disease, liver cirrhosis, osteoporosis, kidney disease, anaemia and increased heart rate (HR) predict mortality, in women heart failure, hyperuricemia, mental disorders, kidney disease and increased HR (p< 0.05 each). Regarding the pulmorbidome, signifcant predictors in men were impairment in difusion capacity and hyperinfation, in women asthma and hyperinfation. Similar results were obtained when repeating the analyses in GOLD 1–4 patients only. Gender diferences should be considered in COPD risk assessment for a tailored approach towards the treatment of COPD.
DOI der Erstveröffentlichung: 10.1038/s41598-022-12828-8
URL der Erstveröffentlichung: https://www.nature.com/articles/s41598-022-12828-8
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-367098
hdl:20.500.11880/33353
http://dx.doi.org/10.22028/D291-36709
ISSN: 2045-2322
Datum des Eintrags: 8-Jul-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Information
In Beziehung stehendes Objekt: https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-022-12828-8/MediaObjects/41598_2022_12828_MOESM1_ESM.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons