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Titel: Quality of Life in NSCLC Survivors : A Multicenter Cross-Sectional Study
VerfasserIn: Hechtner, Marlene
Eichler, Martin
Wehler, Beatrice
Buhl, Roland
Sebastian, Martin
Stratmann, Jan
Schmidberger, Heinz
Gohrbandt, Bernhard
Peuser, Jessica
Kortsik, Cornelius
Nestle, Ursula
Wiesemann, Sebastian
Wirtz, Hubert
Wehler, Thomas
Bals, Robert
Blettner, Maria
Singer, Susanne
Sprache: Englisch
Titel: Journal of Thoracic Oncology
Bandnummer: 14 (2019)
Heft: 3
Seiten: 420-435
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2018
Freie Schlagwörter: Quality of life
Patient-reported outcome
Lung cancer
Survivor
Predictor
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Introduction: The objective was to assess quality of life (QoL) in lung cancer survivors, compare it to the general population, and identify factors associated with global QoL, physical functioning, emotional functioning, fatigue, pain, and dyspnea. Methods: Data from NSCLC patients who had survived 1 year or longer after diagnosis were collected crosssectionally in a multicenter study. QoL was assessed with the European Organisation for the Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30 and the lung cancer module QLQ-LC13 across different clinical subgroups and compared to age- and sex-standardized general population reference values. Multivariable linear regression analyses were performed to test the associations of patient-, tumor-, and treatmentrelated factors with the six primary QoL scales. Results: Six hundred fifty-seven NSCLC patients participated in the study with a median time since diagnosis of 3.7 years (range, 1.0–21.2 years). Compared to the age- and sex-standardized general population, clinically meaningful differences in the QoL detriment were found on almost all domains: lung cancer survivors had clinically relevant poorer global QoL (10 points, p < 0.001). Whereas in 12 months or longer treatment-free patients this detriment was small (8.3), it was higher in patients currently in treatment (16.0). Regarding functioning and symptom scales, respective detriments were largest for dyspnea (41 points), role function (33 points), fatigue (27 points), social function (27 points), physical function (24 points), and insomnia (21 points) observed across all subgroups. The main factor associated with poorer QoL in all primary QoL scales was mental distress (b j19-31j, all p < 0.001). Detriments in QoL across multiple primary QoL scales were also observed with current treatment (b j8-12j, p < 0.01), respiratory comorbidity (b j4-5j, p < 0.01), and living on a disability pension (b j10-11j, p < 0.01). The main factor associated with better QoL in almost all primary QoL scales was higher physical activity (b j10-20j, p < 0.001). Better QoL was also observed in patients with high income (b j10- 14j, p < 0.01). Conclusions: Lung cancer survivors experience both functional restrictions and symptoms that persist long term after active treatment ends. This substantiates the importance of providing long-term supportive care.
DOI der Erstveröffentlichung: 10.1016/j.jtho.2018.11.019
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/pii/S155608641833497X
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-367047
hdl:20.500.11880/33348
http://dx.doi.org/10.22028/D291-36704
ISSN: 1556-0864
Datum des Eintrags: 8-Jul-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Data
In Beziehung stehendes Objekt: https://ars.els-cdn.com/content/image/1-s2.0-S155608641833497X-mmc1.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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