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doi:10.22028/D291-36698
Titel: | Cardiovascular risk in patients with alpha-1-antitrypsin deficiency |
VerfasserIn: | Fähndrich, Sebastian Biertz, Frank Karch, Annika Kleibrink, Björn Koch, Armin Teschler, Helmut Welte, Tobias Kauczor, Hans-Ulrich Janciauskiene, Sabina Jörres, Rudolf A. Greulich, Timm Vogelmeier, Claus F. Bals, Robert |
Sprache: | Englisch |
Titel: | Respiratory Research |
Bandnummer: | 18 |
Heft: | 1 |
Verlag/Plattform: | BMC |
Erscheinungsjahr: | 2017 |
Freie Schlagwörter: | Alpha-1-antitrypsin deficiency Phenotype Cardiovascular disease Emphysema Personalized medicine |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients with AATDrelated lung diseases are not well defined. The aim of this study was to analyze the clinical phenotype of AATD patients within the German COPD cohort study COSYCONET (“COPD and SYstemic consequences-COmorbidities NETwork”) cohort focusing on the distribution of comorbidities. Method and results: The data from 2645 COSYCONET patients, including 139 AATD patients (110 with and 29 without augmentation therapy), were analyzed by descriptive statistics and regression analyses. We found significantly lower prevalence of cardiovascular comorbidities in AATD patients as compared to non-AATD COPD patients. After correction for age, pack years, body mass index, and sex, the differences were still significant for coronary artery disease (p = 0.002) and the prevalence of peripheral artery disease as determined by an ankle-brachial-index <= 0.9 (p = 0.035). Also the distribution of other comorbidities such as bronchiectasis differed between AATD and non-deficient COPD. Conclusion: AATD is associated with a lower prevalence of cardiovascular disease, the underlying mechanisms need further investigation. |
DOI der Erstveröffentlichung: | 10.1186/s12931-017-0655-1 |
URL der Erstveröffentlichung: | https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-017-0655-1 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-366987 hdl:20.500.11880/33342 http://dx.doi.org/10.22028/D291-36698 |
ISSN: | 1465-993X |
Datum des Eintrags: | 7-Jul-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Additional file |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-017-0655-1/MediaObjects/12931_2017_655_MOESM1_ESM.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Robert Bals |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s12931-017-0655-1.pdf | 920,64 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons