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doi:10.22028/D291-36688
Titel: | Consequences of chronic kidney disease in chronic obstructive pulmonary disease |
VerfasserIn: | Trudzinski, Franziska C. Alqudrah, Mohamad Omlor, Albert Zewinger, Stephen Fliser, Danilo Speer, Timotheus Seiler, Frederik Biertz, Frank Koch, Armin Vogelmeier, Claus Welte, Tobias Watz, Henrik Waschki, Benjamin Fähndrich, Sebastian Jörres, Rudolf Bals, Robert |
Sprache: | Englisch |
Titel: | Respiratory Research |
Bandnummer: | 20 |
Heft: | 1 |
Verlag/Plattform: | BMC |
Erscheinungsjahr: | 2019 |
Freie Schlagwörter: | Chronic obstructive pulmonary disease Chronic kidney disease Patient-centered outcomes Cohort study |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: The combination of chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) is associated with a higher prevalence of comorbidities and increased mortality. The impact of kidney function on patient-centered outcomes in COPD has not been evaluated. Methods: Patients from the German COPD and Systemic Consequences - Comorbidities Network (COSYCONET) cohort COPD were analysed. CKD was diagnosed if the estimated glomerular filtration rate (eGFR) measurements were < 60 mL/min/1.73m2 at study inclusion and six month later. The effect of CKD, on comorbidities, symptoms [modified British Medical Research Council dyspnoea scale], physical capacity [six-minute walk test, and timed up and go] and St George’s Respiratory Questionnaire were analysed. Restricted cubic spline models were used to evaluate a nonlinear relationship between eGFR with patient-centered outcomes, cox survival analysis was applied to evaluate mortality. Results: 2274 patients were analysed, with CKD diagnosed in 161 (7.1%). Spline models adjusted for age, gender, BMI, FEV1 and cardiovascular comorbidities revealed independent associations between eGFR with modified British Medical Research Council dyspnoea scale, St George’s Respiratory Questionnaire, (p < 0.001 and p = 0.011), six-minute walk test (p = 0.015) and timed up and go (p < 0.001). CKD was associated with increased mortality, independently from for other cardiovascular comorbidities (hazard ratio 2.3; p < 0.001). Conclusion: These data show that CKD is a relevant comorbidity in COPD patients which impacts on patient-centered outcomes and mortality. |
DOI der Erstveröffentlichung: | 10.1186/s12931-019-1107-x |
URL der Erstveröffentlichung: | https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1107-x |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-366887 hdl:20.500.11880/33332 http://dx.doi.org/10.22028/D291-36688 |
ISSN: | 1465-993X |
Datum des Eintrags: | 7-Jul-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Additional file |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-019-1107-x/MediaObjects/12931_2019_1107_MOESM1_ESM.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Robert Bals M - Dr. med. Dr. sc.nat. Timo Speer |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s12931-019-1107-x.pdf | 914,36 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons