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Titel: Consequences of chronic kidney disease in chronic obstructive pulmonary disease
VerfasserIn: Trudzinski, Franziska C.
Alqudrah, Mohamad
Omlor, Albert
Zewinger, Stephen
Fliser, Danilo
Speer, Timotheus
Seiler, Frederik
Biertz, Frank
Koch, Armin
Vogelmeier, Claus
Welte, Tobias
Watz, Henrik
Waschki, Benjamin
Fähndrich, Sebastian
Jörres, Rudolf
Bals, Robert
Sprache: Englisch
Titel: Respiratory Research
Bandnummer: 20
Heft: 1
Verlag/Plattform: BMC
Erscheinungsjahr: 2019
Freie Schlagwörter: Chronic obstructive pulmonary disease
Chronic kidney disease
Patient-centered outcomes
Cohort study
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: The combination of chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) is associated with a higher prevalence of comorbidities and increased mortality. The impact of kidney function on patient-centered outcomes in COPD has not been evaluated. Methods: Patients from the German COPD and Systemic Consequences - Comorbidities Network (COSYCONET) cohort COPD were analysed. CKD was diagnosed if the estimated glomerular filtration rate (eGFR) measurements were < 60 mL/min/1.73m2 at study inclusion and six month later. The effect of CKD, on comorbidities, symptoms [modified British Medical Research Council dyspnoea scale], physical capacity [six-minute walk test, and timed up and go] and St George’s Respiratory Questionnaire were analysed. Restricted cubic spline models were used to evaluate a nonlinear relationship between eGFR with patient-centered outcomes, cox survival analysis was applied to evaluate mortality. Results: 2274 patients were analysed, with CKD diagnosed in 161 (7.1%). Spline models adjusted for age, gender, BMI, FEV1 and cardiovascular comorbidities revealed independent associations between eGFR with modified British Medical Research Council dyspnoea scale, St George’s Respiratory Questionnaire, (p < 0.001 and p = 0.011), six-minute walk test (p = 0.015) and timed up and go (p < 0.001). CKD was associated with increased mortality, independently from for other cardiovascular comorbidities (hazard ratio 2.3; p < 0.001). Conclusion: These data show that CKD is a relevant comorbidity in COPD patients which impacts on patient-centered outcomes and mortality.
DOI der Erstveröffentlichung: 10.1186/s12931-019-1107-x
URL der Erstveröffentlichung: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1107-x
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-366887
hdl:20.500.11880/33332
http://dx.doi.org/10.22028/D291-36688
ISSN: 1465-993X
Datum des Eintrags: 7-Jul-2022
Bezeichnung des in Beziehung stehenden Objekts: Additional file
In Beziehung stehendes Objekt: https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-019-1107-x/MediaObjects/12931_2019_1107_MOESM1_ESM.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
M - Dr. med. Dr. sc.nat. Timo Speer
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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