Please use this identifier to cite or link to this item: doi:10.22028/D291-36677
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Title: The Homburg Lung : Efficacy and Safety of a Minimal-Invasive Pump-Driven Device for Veno-Venous Extracorporeal Carbon Dioxide Removal
Author(s): Seiler, Frederik
Trudzinski, Franziska C.
Hennemann, Kai
Niermeyer, Tom
Schmoll, Christian
Kamp, Annegret
Bals, Robert
Muellenbach, Ralf M.
Haake, Hendrik
Lepper, Philipp M.
Language: English
Title: ASAIO Journal
Volume: 63
Issue: 5
Pages: 659-665
Publisher/Platform: American Society for Artificial Internal Organs
Year of Publication: 2017
Free key words: ECCO2 R
hypercapnia
ventilatory failure
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Extracorporeal carbon dioxide removal (ECCO2R) is increasingly considered a viable therapeutic approach in the management of hypercapnic lung failure to avoid intubation or to allow lung-protective ventilator settings. This study aimed to analyze efficacy and safety of a minimal-invasive ECCO2R device, the Homburg lung. The Homburg lung is a pump-driven system for veno-venous ECCO2R with ¼″ tubing and a 0.8 m2 surface oxygenator. Vascular access is usually established via a 19F/21 cm bilumen cannula in the right internal jugular vein. For this work, we screened patient registries from two German centers for patients who underwent ECCO2R with the Homburg lung because of hypercapnic lung failure since 2013. Patients who underwent extracorporeal membrane oxygenation before ECCO2R were excluded. Patients who underwent ECCO2R more than one time were only included once. In total, 24 patients (aged 53.86 ± 12.49 years; 62.5% male) were included in the retrospective data analysis. Ventilatory failure occurred because of chronic obstructive pulmonary disease (50%), cystic fibrosis (16.7%), acute respiratory distress syndrome (12.5%), and other origins (20.8%). The system generated a blood flow of 1.18 ± 0.23 liters per minute (lpm). Sweep gas flow was 3.87 ± 2.97 lpm. Within 4 hours, paCO2 could be reduced significantly from 82.05 ± 15.57 mm Hg to 59.68 ± 12.27 mm Hg, thereby, increasing pH from 7.23 ± 0.10 to 7.36 ± 0.09. Cannulation-associated complications were transient arrhythmia (1/24 patients) and air embolism (1/24). Fatal complications did not occur. In conclusion, the Homburg lung provides effective carbon dioxide removal in hypercapnic lung failure. The cannulation is a safe procedure, with complication rates comparable to those in central venous catheter implantation.
DOI of the first publication: 10.1097/MAT.0000000000000522
URL of the first publication: https://journals.lww.com/asaiojournal/Fulltext/2017/09000/The_Homburg_Lung__Efficacy_and_Safety_of_a.22.aspx
Link to this record: urn:nbn:de:bsz:291--ds-366771
hdl:20.500.11880/33320
http://dx.doi.org/10.22028/D291-36677
ISSN: 1058-2916
Date of registration: 7-Jul-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Robert Bals
Collections:Die Universitätsbibliographie

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