Please use this identifier to cite or link to this item: doi:10.22028/D291-36676
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Title: Altered blood levels of vitamin D, cathelicidin and parathyroid hormone in patients with sepsis : a pilot study
Author(s): Greulich, T.
Regner, W.
Branscheidt, M.
Herr, C.
Koczulla, A. R.
Vogelmeier, C. F.
Bals, R.
Language: English
Title: Anaesthesia and Intensive Care
Volume: 45
Issue: 1
Pages: 36-45
Publisher/Platform: SAGE Journals
Year of Publication: 2017
Free key words: SIRS
sepsis
vitamin D
cholecalciferol
parathyroid hormone
cathelicidin
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: It has been recognised that vitamin D (VitD) has a potential role in the regulation of inflammation and protection from infection. In a prospective clinical observational pilot study, we investigated the serum levels of 25-hydroxyvitamin-D3 (25(OH D3), 1,25-hydroxyvitamin-D3 (1,25(OH)2D3), parathyroid hormone (PTH), and cathelicidin in intensive care unit (ICU) patients with or without systemic inflammatory response syndrome (SIRS). We included 32 patients with SIRS (septic patients), 16 ICU patients without SIRS, and 16 healthy controls. To substantiate the findings of the clinical study, we stimulated monocyte-derived macrophages with microbial patterns and analysed the impact of VitD on release of cytokines and antimicrobial activity. We found that patients with or without SIRS had relatively low levels of 25(OH)D3 and 1,25(OH)2D3. Patients with sepsis had significantly lower levels of 25(OH)D3 as compared to ICU control patients and healthy controls (10.53 ± 11.3 µg/l versus 16.46 ± 12.58 µg/l versus 24.04 ± 12.07 µg/l); the same was true for 1,25(OH)2D3. Serum levels of PTH and cathelicidin were significantly increased in sepsis patients, as compared to the other groups. In vitro, VitD significantly decreased the release of pro-inflammatory cytokines from macrophages and increased the antimicrobial activity of the cells. We concluded that patients with sepsis have significantly lower VitD levels. In vitro, VitD modulates inflammation and increases the antibacterial activity of innate immune cells. These findings suggest that VitD insufficiency is mechanistically related to increased susceptibility to SIRS and sepsis.
DOI of the first publication: 10.1177/0310057X1704500106
URL of the first publication: https://journals.sagepub.com/doi/10.1177/0310057X1704500106
Link to this record: urn:nbn:de:bsz:291--ds-366760
hdl:20.500.11880/33319
http://dx.doi.org/10.22028/D291-36676
ISSN: 0310-057X
Date of registration: 7-Jul-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Robert Bals
Collections:Die Universitätsbibliographie

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