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Titel: Left ventricular volume and wall stress are linked to lung function impairment in COPD
VerfasserIn: Alter, Peter
Jörres, Rudolf A.
Watz, Henrik
Welte, Tobias
Gläser, Sven
Schulz, Holger
Bals, Robert
Karch, Annika
Wouters, Emiel F. M.
Vestbo, Jørgen
Young, David
Vogelmeier, Claus F.
Sprache: Englisch
Titel: International Journal of Cardiology
Bandnummer: 261
Seiten: 172-178
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2018
Freie Schlagwörter: COPD
Airflow limitation
Hyperinflation
Heart failure
Ventricular wall stress
Dyspnea
Breathing
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background Cardiovascular comorbidities are common in chronic obstructive pulmonary disease (COPD). We examined the association between airflow limitation, hyperinflation and the left ventricle (LV). Methods Patients from the COPD cohort COSYCONET underwent evaluations including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), effective airway resistance (Reff), intrathoracic gas volume (ITGV), and echocardiographic LV end-diastolic volume (LVEDV), stroke volume (LVSV), end-systolic volume (LVESV), and end-diastolic and end-systolic LV wall stress. Data from Visit 1 (baseline) and Visit 3 (18 months later) were used. In addition to comparisons of both visits, multivariate regression analysis was conducted, followed by structural equation modelling (SEM) with latent variables “Lung” and “Left heart”. Results A total of 641 participants were included in this analysis. From Visit 1 to Visit 3, there were significant declines in FEV1 and FEV1/FVC, and increases in Reff, ITGV and LV end-diastolic wall stress, and a borderline significant decrease in LV mass. There were significant correlations of: FEV1% predicted with LVEDV and LVSV; Reff with LVSV; and ITGV with LV mass and LV end-diastolic wall stress. The SEM fitted the data of both visits well (comparative fit index: 0.978, 0.962), with strong correlation between “Lung” and “Left heart”. Conclusions We demonstrated a relationship between lung function impairment and LV wall stress in patients with COPD. This supports the hypothesis that LV impairment in COPD could be initiated or promoted, at least partly, by mechanical factors exerted by the lung disorder.
DOI der Erstveröffentlichung: 10.1016/j.ijcard.2018.02.074
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/abs/pii/S016752731736059X
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-366645
hdl:20.500.11880/33304
http://dx.doi.org/10.22028/D291-36664
ISSN: 0167-5273
Datum des Eintrags: 6-Jul-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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