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Titel: Relationship of hyperlipidemia to comorbidities and lung function in COPD: Results of the COSYCONET cohort
VerfasserIn: Kahnert, Kathrin
Lucke, Tanja
Huber, Rudolf M.
Behr, Jürgen
Biertz, Frank
Vogt, Anja
Watz, Henrik
Alter, Peter
Fähndrich, Sebastian
Bals, Robert
Holle, Rolf
Karrasch, Stefan
Söhler, Sandra
Wacker, Margarethe
Ficker, Joachim H.
Parhofer, Klaus G.
Vogelmeier, Claus
Jörres, Rudolf A.
Sprache: Englisch
Titel: PloS One
Bandnummer: 12
Heft: 5
Verlag/Plattform: PLOS
Erscheinungsjahr: 2017
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Although hyperlipidemia is common in COPD, its relationship to comorbidities, risk factors and lung function in COPD has not been studied in detail. Using the baseline data of the COSYCONET cohort we addressed this question. Data from 1746 COPD patients (GOLD stage 1–4; mean age 64.6 y, mean FEV1%pred 57%) were evaluated, focusing on the comorbidities hyperlipidemia, diabetes and cardiovascular complex (CVC; including arterial hypertension, cardiac failure, ischemic heart disease). Risk factors comprised age, gender, BMI, and packyears of smoking. The results of linear and logistic regression analyses were implemented into a path analysis model describing the multiple relationships between parameters. Hyperlipidemia (prevalence 42.9%) was associated with lower intrathoracic gas volume (ITGV) and higher forced expiratory volume in 1 second (FEV1) when adjusting for its multiple relationships to risk factors and other comorbidities. These findings were robust in various statistical analyses. The associations between comorbidities and risk factors were in accordance with previous findings, thereby underlining the validity of our data. In conclusion, hyperlipidemia was associated with less hyperinflation and airway obstruction in patients with COPD. This surprising result might be due to different COPD phenotypes in these patients or related to effects of medication.
DOI der Erstveröffentlichung: 10.1371/journal.pone.0177501
URL der Erstveröffentlichung: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177501
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-366602
hdl:20.500.11880/33300
http://dx.doi.org/10.22028/D291-36660
ISSN: 1932-6203
Datum des Eintrags: 6-Jul-2022
Bezeichnung des in Beziehung stehenden Objekts: Supporting information
In Beziehung stehendes Objekt: https://doi.org/10.1371/journal.pone.0177501.s001
https://doi.org/10.1371/journal.pone.0177501.s002
https://doi.org/10.1371/journal.pone.0177501.s003
https://doi.org/10.1371/journal.pone.0177501.s004
https://doi.org/10.1371/journal.pone.0177501.s005
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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