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doi:10.22028/D291-36658
Titel: | Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients |
VerfasserIn: | Karl, Florian M. Holle, Rolf Bals, Robert Greulich, Timm Jörres, Rudolf A. Karch, Annika Koch, Armin Karrasch, Stefan Leidl, Reiner Schulz, Holger Vogelmeier, Claus Wacker, Margarethe E. |
Sprache: | Englisch |
Titel: | Respiratory Research |
Bandnummer: | 18 |
Heft: | 1 |
Verlag/Plattform: | BMC |
Erscheinungsjahr: | 2017 |
Freie Schlagwörter: | COPD Alpha-1-Antitrypsin Deficiency Direct costs Indirect costs Health-related quality of life Augmentation therapy |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Alpha-1-Antitrypsin Deficiency (AATD) is an economically unexplored genetic disease. Methods: Direct and indirect costs (based on self-reported information on healthcare utilization) and health-related quality of life (HRQL, as assessed by SGRQ, CAT, and EQ-5D-3 L) were compared between 131 AATD patients (106 with, 25 without augmentation therapy (AT)) and 2,049 COPD patients without AATD participating in the COSYCONET COPD cohort. The medication costs of AT were excluded from all analyses to reveal differences associated with morbidity profiles. The association of AATD (with/without AT) with costs or HRQL was examined using generalized linear regression modelling (GLM) adjusting for age, sex, GOLD grade, BMI, smoking status, education and comorbidities. Results: Adjusted mean direct annual costs were €6,099 in AATD patients without AT, €7,117 in AATD patients with AT (excluding costs for AT), and €7,460 in COPD patients without AATD. AATD with AT was significantly associated with higher outpatient (+273%) but lower inpatient (−35%) and medication costs (−10%, disregarding AT) compared with COPD patients without AATD. There were no significant differences between groups regarding indirect costs and HRQL. Conclusion: Apart from AT costs, AATD patients tended to have lower, though not significant, overall costs and similar HRQL compared to COPD patients without AATD. AT was not associated with lower costs or higher HRQL. |
DOI der Erstveröffentlichung: | 10.1186/s12931-017-0543-8 |
URL der Erstveröffentlichung: | https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-017-0543-8 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-366581 hdl:20.500.11880/33298 http://dx.doi.org/10.22028/D291-36658 |
ISSN: | 1465-993X |
Datum des Eintrags: | 6-Jul-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Additional files |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-017-0543-8/MediaObjects/12931_2017_543_MOESM1_ESM.doc https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-017-0543-8/MediaObjects/12931_2017_543_MOESM2_ESM.doc https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-017-0543-8/MediaObjects/12931_2017_543_MOESM3_ESM.doc https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-017-0543-8/MediaObjects/12931_2017_543_MOESM4_ESM.doc https://static-content.springer.com/esm/art%3A10.1186%2Fs12931-017-0543-8/MediaObjects/12931_2017_543_MOESM5_ESM.doc |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Robert Bals |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s12931-017-0543-8.pdf | 629,93 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons