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Titel: Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort
VerfasserIn: Kahnert, Kathrin
Lucke, Tanja
Biertz, Frank
Lechner, Andreas
Watz, Henrik
Alter, Peter
Bals, Robert
Behr, Jürgen
Holle, Rolf
Huber, Rudolf M.
Karrasch, Stefan
Stubbe, Beate
Wacker, Margarethe
Söhler, Sandra
Wouters, Emiel F. M.
Vogelmeier, Claus
Jörres, Rudolf A.
Sprache: Englisch
Titel: Respiratory Research
Bandnummer: 18
Heft: 1
Verlag/Plattform: BMC
Erscheinungsjahr: 2017
Freie Schlagwörter: COPD
Diabetes
Lung function
Diffusing capacity
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. Methods: Data from the initial visit of the German COPD cohort COSYCONET were used for analysis. 2575 patients with complete lung function data were included, among them 358 defined as diabetics with a reported physician diagnosis of diabetes and/or specific medication. Pairwise comparisons between groups and multivariate regression models were used to identify variables predicting the CO transfer factor (TLCO%pred) and the transfer coefficient (KCO%pred). Results: COPD patients with diabetes differed from those without diabetes regarding lung function, anthropometric, clinical and laboratory parameters. Moreover, gender was an important covariate. After correction for lung function, gender and body mass index (BMI), TLCO%pred did not significantly differ between patients with and without diabetes. The results for the transfer coefficient KCO were similar, demonstrating an important role of the confounding factors RV%pred, TLC%pred, ITGV%pred, FEV1%pred, FEV1/FVC, age, packyears, creatinine and BMI. There was not even a tendency towards lower values in diabetes. Conclusion: The analysis of data from a COPD cohort showed no significant differences of CO transport parameters between COPD patients with and without diabetes, if BMI, gender and the reduction in lung volumes were taken into account. This result is in contrast to observations in lung-healthy subjects with diabetes and raises the question which factors, among them potential anti-inflammatory effects of anti-diabetes medication are responsible for this finding.
DOI der Erstveröffentlichung: 10.1186/s12931-016-0499-0
URL der Erstveröffentlichung: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-016-0499-0
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-366566
hdl:20.500.11880/33296
http://dx.doi.org/10.22028/D291-36656
ISSN: 1465-993X
Datum des Eintrags: 6-Jul-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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