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Titel: Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study
VerfasserIn: Houben-Wilke, Sarah
Jörres, Rudolf A.
Bals, Robert
Franssen, Frits M. E.
Gläser, Sven
Holle, Rolf
Karch, Annika
Koch, Armin
Magnussen, Helgo
Obst, Anne
Schulz, Holger
Spruit, Martijn A.
Wacker, Margarethe E.
Welte, Tobias
Wouters, Emiel F. M.
Vogelmeier, Claus
Watz, Henrik
Sprache: Englisch
Titel: American Journal of Respiratory and Critical Care Medicine
Bandnummer: 195
Heft: 2
Seiten: 189-197
Verlag/Plattform: American Thoracic Society
Erscheinungsjahr: 2017
Freie Schlagwörter: chronic obstructive pulmonary disease
comorbidities
peripheral vascular disease
health status
functional capacity
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Rationale: Knowledge about the prevalence of objectively assessed peripheral artery disease (PAD) and its clinical relevance in patients with chronic obstructive pulmonary disease (COPD) is scarce. Objectives: We aimed to: (1) assess the prevalence of PAD in COPD compared with distinct control groups; and (2) study the association between PAD and functional capacity as well as health status. Methods: The ankle–brachial index was used to diagnose PAD (ankle–brachial index ≤ 0.9). The 6-minute-walk distance, health status (St. George’s Respiratory Questionnaire), COPD Assessment Test, and EuroQol-5-Dimensions were assessed in patients enrolled in the German COPD and Systemic Consequences–Comorbidities Network cohort study. Control groups were derived from the Study of Health in Pomerania. Measurements and Main Results: A total of 2,088 patients with COPD (61.1% male; mean [SD] age, 65.3 [8.2] years, GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I–IV: 9.4, 42.5, 37.5, and 10.5%, respectively) were included, of which 184 patients (8.8%; GOLD stage I–IV: 5.1, 7.4, 11.1, and 9.5%, respectively, vs. 5.9% in patients with GOLD stage 0 in the COPD and Systemic Consequences–Comorbidities Network) had PAD. In the Study of Health in Pomerania, PAD ranged from 1.8 to 4.2%. Patients with COPD with PAD had a significantly shorter 6-minute-walk distance (356 [108] vs. 422 [103] m, P < 0.001) and worse health status (St. George’s Respiratory Questionnaire: 49.7 [20.1] vs. 42.7 [20.0] points, P < 0.001; COPD Assessment Test: 19.6 [7.4] vs. 17.9 [7.4] points, P = 0.004; EuroQol-5-Dimensions visual analog scale: 51.2 [19.0] vs. 57.2 [19.6], P < 0.001). Differences remained significant after correction for several confounders. Conclusions: In a large cohort of patients with COPD, 8.8% were diagnosed with PAD, which is higher than the prevalence in control subjects without COPD. PAD was associated with a clinically relevant reduction in functional capacity and health status.
DOI der Erstveröffentlichung: 10.1164/rccm.201602-0354OC
URL der Erstveröffentlichung: https://www.atsjournals.org/doi/10.1164/rccm.201602-0354OC
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-366546
hdl:20.500.11880/33293
http://dx.doi.org/10.22028/D291-36654
ISSN: 1535-4970
1073-449X 1
Datum des Eintrags: 6-Jul-2022
Bezeichnung des in Beziehung stehenden Objekts: Online supplement
In Beziehung stehendes Objekt: https://www.atsjournals.org/doi/suppl/10.1164/rccm.201602-0354OC/suppl_file/disclosures.pdf
https://www.atsjournals.org/doi/suppl/10.1164/rccm.201602-0354OC/suppl_file/houben-wilke_data_supplement.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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