Please use this identifier to cite or link to this item: doi:10.22028/D291-36548
Title: Microbiological airway colonization in COPD patients with severe emphysema undergoing endoscopic lung volume reduction
Author(s): Trudzinski, Franziska C.
Seiler, Frederik
Wilkens, Heinrike
Metz, Carlos
Kamp, Annegret
Bals, Robert
Gärtner, Barbara
Lepper, Philipp M.
Becker, Sören L.
Language: English
Title: International Journal of Chronic Obstructive Pulmonary Disease
Volume: 13
Pages: 29—35
Publisher/Platform: DOVE Medical Press
Year of Publication: 2017
Free key words: COPD
endoscopic lung volume reduction
Haemophilus influenzae
Pseudomonas aeruginosa
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background: Endoscopic lung volume reduction (eLVR) is a therapeutic option for selected patients with COPD and severe emphysema. Infectious exacerbations are serious events in these vulnerable patients; hence, prophylactic antibiotics are often prescribed postinterventionally. However, data on the microbiological airway colonization at the time of eLVR are scarce, and there are no evidence-based recommendations regarding a rational antibiotic regimen. Objective: The aim of this study was to perform a clinical and microbiological analysis of COPD patients with advanced emphysema undergoing eLVR with endobronchial valves at a single German University hospital, 2012–2017. Patients and methods: Bronchial aspirates were obtained prior to eLVR and sent for microbiological analysis. Antimicrobial susceptibility testing of bacterial isolates was performed, and pathogen colonization was retrospectively compared with clinical parameters. Results: At least one potential pathogen was found in 47% (30/64) of patients. Overall, Gram-negative bacteria constituted the most frequently detected pathogens. The single most prevalent species were Haemophilus influenzae (9%), Streptococcus pneumoniae (6%), and Staphylococcus aureus (6%). No multidrug resistance was observed, and Pseudomonas aeruginosa occurred in 5% of samples. Patients without microbiological airway colonization showed more severe airflow limitation, hyperinflation, and chronic hypercapnia compared to those with detected pathogens. Conclusion: Microbiological airway colonization was frequent in patients undergoing eLVR but not directly associated with poorer functional status. Resistance testing results do not support the routine use of antipseudomonal antibiotics in these patients.
DOI of the first publication: 10.2147/COPD.S150705
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-365481
ISSN: 1178-2005
Date of registration: 22-Jun-2022
Faculty: M - Medizinische Fakultät
Department: M - Infektionsmedizin
M - Innere Medizin
Professorship: M - Prof. Dr. Robert Bals
M - Prof. Dr. Sören Becker
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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