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doi:10.22028/D291-36429
Titel: | Preoperative Sonographic Prediction of Limited Axillary Disease in Patients with Primary Breast Cancer Meeting the Z0011 Criteria: an Alternative to Sentinel Node Biopsy? |
VerfasserIn: | Radosa, Julia Caroline Solomayer, Erich-Franz Deeken, Martin Minko, Peter Zimmermann, Julia Sarah Maria Kaya, Askin Canguel Radosa, Marc Philipp Stotz, Lisa Huwer, Sarah Müller, Carolin Karsten, Maria Margarete Wagenpfeil, Gudrun Radosa, Christoph Georg |
Sprache: | Englisch |
Titel: | Annals of Surgical Oncology |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2022 |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Purpose To assess the accuracy of preoperative sonographic staging for prediction of limited axillary disease (LAD, one or two metastatic lymph nodes) and to identify factors associated with high prediction–pathology concordance in patients with early-stage breast cancer meeting the Z0011 criteria. Materials and Methods Patients treated between January 2015 and January 2020 were included in this retrospective, multicentric analysis of prospectively acquired service databases. The accuracy of LAD prediction was assessed separately for patients with one and two suspicious lymph nodes on preoperative sonography. Test validity outcomes for LAD prediction were calculated for both groups, and a multivariate model was used to identify factors associated with high accuracy of LAD prediction. Results Of 2059 enrolled patients, 1513 underwent sentinel node biopsy, 436 primary and 110 secondary axillary dissection. For LAD prediction in patients with one suspicious lymph node on preoperative ultrasound, sensitivity was 92% (95% CI 87–95%), negative predictive value (NPV) was 92% (95% CI 87–95%), and the false-negative rate (FNR) was 8% (95% CI 5–13%). For patients with two preoperatively suspicious nodes, the sensitivity, NPV, and FNR were 89% (95% CI 84–93%), 73% (62–83%), and 11% (95% CI 7–16%), respectively. On multivariate analysis, the number of suspicious lymph nodes was associated inversely with correct LAD prediction ([OR 0.01 (95% CI 0.01–0.93), p ≤ 0.01]. Conclusions Sonographic axillary staging in patients with one metastatic lymph node predicted by preoperative ultrasound showed high accuracy and a false-negative rate comparable to sentinel node biopsy for prediction of limited axillary disease. |
DOI der Erstveröffentlichung: | 10.1245/s10434-022-11829-1 |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1245/s10434-022-11829-1 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-364293 hdl:20.500.11880/33074 http://dx.doi.org/10.22028/D291-36429 |
ISSN: | 1534-4681 1068-9265 |
Datum des Eintrags: | 10-Jun-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Frauenheilkunde M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | M - Prof. Dr. E.-F. Solomayer M - Prof. Dr. Stefan Wagenpfeil |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Radosa2022_Article_PreoperativeSonographicPredict.pdf | 319,55 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons