Please use this identifier to cite or link to this item: doi:10.22028/D291-36396
Title: Complete remission of an early-stage laryngeal cancer under combined pembrolizumab and chemotherapy treatment of a synchronous lung adenocarcinoma
Author(s): Linxweiler, Maximilian
Kühn, Jan Philipp
Neubert, Christian
Khreish, Fadi
Balensiefer, Benedikt
Wagner, Mathias
Schick, Bernhard
Language: English
Title: Journal of Otolaryngology - Head & Neck Surgery
Volume: 51
Issue: 1
Publisher/Platform: BMC
Year of Publication: 2022
Free key words: Head and neck cancer
Early-stage disease
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background: Anti-PD1-Checkpoint inhibition (CI) is an established treatment of recurrent and/or metastatic head and neck cancer. A potential beneft from CI in early-stage disease that is usually treated by radiation or surgery has not been investigated so far and is currently not addressed in clinical trials. Case presentation: A 58-year-old man was diagnosed with a cT2 supraglottic laryngeal cancer and a synchronous metastasized adenocarcinoma of the lung. As the patient refused any treatment of his laryngeal cancer, he received combined immune-chemotherapy according to the KEYNOTE-189 protocol. After 4 cycles of pembrolizumab/carboplatin/pemetrexed, the patient showed a complete remission of his laryngeal cancer with a clear shrinkage of the mediastinal and hilar lung cancer metastases. After 21 cycles of maintenance therapy, the lung adenocarcinoma shows a stable disease status with no signs of any residual or recurrent laryngeal cancer. Conclusions: Anti-PD1-CI may be a treatment option also for early-stage HNSCC with excellent functional outcome when established therapies are not available.
DOI of the first publication: 10.1186/s40463-022-00572-y
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-363961
ISSN: 1916-0216
Date of registration: 8-Jun-2022
Faculty: M - Medizinische Fakultät
Department: M - Hals-Nasen-Ohrenheilkunde
M - Innere Medizin
M - Pathologie
M - Radiologie
Professorship: M - Prof. Dr. Bernhard Schick
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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