Please use this identifier to cite or link to this item: doi:10.22028/D291-36377
Title: Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk
Author(s): Böhm, Michael
Schumacher, Helmut
Werner, Christian
Teo, Koon K.
Lonn, Eva M.
Mahfoud, Felix
Speer, Thimoteus
Mancia, Giuseppe
Redon, Josep
Schmieder, Roland E.
Sliwa, Karen
Marx, Nikolaus
Weber, Michael A.
Laufs, Ulrich
Williams, Bryan
Yusuf, Salim
Mann, Johannes F. E.
Language: English
Title: Cardiovascular Diabetology
Volume: 21
Issue: 1
Publisher/Platform: BMC
Year of Publication: 2022
Free key words: Physical activity
Cardiovascular outcomes
Renal outcomes
Secondary prevention
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background: Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged≥55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods: Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and χ2 - test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results: Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p<0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p=0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p=0.05). Conclusions: Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully difer with or without diabetes but absolute beneft of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration:
DOI of the first publication: 10.1186/s12933-021-01429-w
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-363774
ISSN: 1475-2840
Date of registration: 7-Jun-2022
Description of the related object: Supplementary Information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Michael Böhm
M - Dr. med. Dr. sc.nat. Timo Speer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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