Please use this identifier to cite or link to this item: doi:10.22028/D291-36375
Title: Antibiotics in early life and childhood pre-B-ALL. Reasons to analyze a possible new piece in the puzzle
Author(s): Cardesa-Salzmann, T. M.
Simon, A.
Graf, N.
Language: English
Title: Discover Oncology
Volume: 13
Issue: 1
Publisher/Platform: Springer Nature
Year of Publication: 2022
Free key words: Childhood acute lymphoblastic leukemia
Inherited susceptibility
Innate immune response
Leukemia microenvironment
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with precursor B-cell ALL (pB-ALL) accounting for~85% of the cases. Childhood pB-ALL development is infuenced by genetic susceptibility and host immune responses. The role of the intestinal microbiome in leukemogenesis is gaining increasing attention since Vicente-Dueñas’ seminal work demonstrated that the gut microbiome is distinct in mice genetically predisposed to ALL and that the alteration of this microbiome by antibiotics is able to trigger pB-ALL in Pax5 heterozygous mice in the absence of infectious stimuli. In this review we provide an overview on novel insights on the role of the microbiome in normal and preleukemic hematopoiesis, infammation, the efect of dysbiosis on hematopoietic stem cells and the emerging importance of the innate immune responses in the conversion from preleukemic to leukemic state in childhood ALL. Since antibiotics, which represent one of the most widely used medical interventions, alter the gut microbial composition and can cause a state of dysbiosis, this raises exciting epidemiological questions regarding the implications for antibiotic use in early life, especially in infants with a a preleukemic “frst hit”. Sheading light through a rigorous study on this piece of the puzzle may have broad implications for clinical practice.
DOI of the first publication: 10.1007/s12672-022-00465-6
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-363755
ISSN: 2730-6011
Date of registration: 7-Jun-2022
Faculty: M - Medizinische Fakultät
Department: M - Pädiatrie
Professorship: M - Prof. Dr. Norbert Graf
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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