Please use this identifier to cite or link to this item: doi:10.22028/D291-36358
Title: Periodontitis-Derived Dark-NETs in Severe Covid-19
Author(s): Vitkov, Ljubomir
Knopf, Jasmin
Krunić, Jelena
Schauer, Christine
Schoen, Janina
Minnich, Bernd
Hannig, Matthias
Herrmann, Martin
Language: English
Title: Frontiers in Immunology
Volume: 13
Publisher/Platform: Frontiers
Year of Publication: 2022
Free key words: neutrophil hyper-responsiveness
dysregulated immunity
trained immunity
NET hyper-responsiveness
NET-induced damage
inhibition of NET formation
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: The frequent severe COVID-19 course in patients with periodontitis suggests a link of the aetiopathogenesis of both diseases. The formation of intravascular neutrophil extracellular traps (NETs) is crucial to the pathogenesis of severe COVID-19. Periodontitis is characterised by an increased level of circulating NETs, a propensity for increased NET formation, delayed NET clearance and low-grade endotoxemia (LGE). The latter has an enormous impact on innate immunity and susceptibility to infection with SARS-CoV-2. LPS binds the SARS-CoV-2 spike protein and this complex, which is more active than unbound LPS, precipitates massive NET formation. Thus, circulating NET formation is the common denominator in both COVID-19 and periodontitis and other diseases with low grade endotoxemia like diabetes, obesity and cardiovascular diseases (CVD) also increase the risk to develop severe COVID-19. Here we discuss the role of propensity for increased NET formation, DNase I deficiency and low-grade endotoxaemia in periodontitis as aggravating factors for the severe course of COVID-19 and possible strategies for the diminution of increased levels of circulating periodontitis-derived NETs in COVID-19 with periodontitis comorbidity.
DOI of the first publication: 10.3389/fimmu.2022.872695
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-363586
ISSN: 1664-3224
Date of registration: 3-Jun-2022
Faculty: M - Medizinische Fakultät
Department: M - Zahn-, Mund- und Kieferheilkunde
Professorship: M - Prof. Dr. Matthias Hannig
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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