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Titel: IgG seroprevalence of COVID-19 among people living with HIV or at high risk of HIV in south-west Germany: A seroprevalence study
VerfasserIn: Kaddu-Mulindwa, Dominic
Keuser, Lukas
Lesan, Vadim
Rissland, Jürgen
Smola, Sigrun
Werdecker, Victoria
Stilgenbauer, Stephan
Christofyllakis, Konstantinos
Thurner, Lorenz
Bewarder, Moritz
Lohr, Benedikt
Lutz, Jens
Lohse, Stefan
Rieke, Ansgar
Sprache: Englisch
Titel: HIV Medicine
Bandnummer: 23
Heft: 5
Seiten: 564-569
Verlag/Plattform: Wiley
Erscheinungsjahr: 2021
Freie Schlagwörter: antibody
COVID-19
HIV
SARS-CoV-2
seroprevalence
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Objectives: Seroprevalence studies of SARS-CoV-2 have shown that there is a high number of undiagnosed missing cases. Seroprevalence of SARS-CoV-2 in people living with HIV (PLWH) is lacking. Therefore, we conducted a prospective cross-sectional study to estimate the seroprevalence of SARS-CoV-2 among PLWH without known diagnosis of COVID-19 in the south-west of Germany. Methods: Serological testing for SARS-CoV-2 immunoglobulin G (IgG) antibodies based on two assays was performed in PLWH who visited the outpatient HIV centre of two hospitals from April to June 2020. Additionally, patients had to answer questionnaires about possible COVID-19-related symptoms and predefined risk factors. Moreover, we tested 50 non-HIV-infected patients receiving post- or pre-exposure (PEP/PrEP) HIV prophylaxis. Results: In all, 594 (488 male, 106 female) PLWH (median age 51 years) and 50 PEP/PrEP-users were included in the study. The estimated seroprevalence of the PLWH cohort was 1.85% (11/594), with 11 positive tested cases in the cohort. Among all patients, only five had COVID-19-related symptoms. One PCRpositive patient did not show any antibody response in repeatedly carried out tests. None of the patients was hospitalized due to COVID-19. Three PrEP users were tested positive. Three patients had been previously diagnosed with SARSCOV-2 infection before inclusion. The used questionnaire did not help to detect SARS-CoV-2 positive patients. Conclusions: Despite the limitation of being only a snapshot in time because of the ongoing pandemic, to our knowledge this is the largest study so far on seroprevalence of SARS-CoV-2 in PLWH in Germany. Our study suggests that the seroprevalence of SARS-CoV-2 in PLWH is comparable to those previously reported for parts of the general German population and that the questionnaire used here might not be the best tool to predict COVID-19 diagnosis.
DOI der Erstveröffentlichung: 10.1111/hiv.13207
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-363115
hdl:20.500.11880/32983
http://dx.doi.org/10.22028/D291-36311
ISSN: 1468-1293
1464-2662
Datum des Eintrags: 31-Mai-2022
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fhiv.13207&file=hiv13207-sup-0001-TableS1.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Infektionsmedizin
M - Innere Medizin
Professur: M - Prof. Dr. Stephan Stilgenbauer
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



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